Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Clobazam
Drug ID BADD_D00488
Description Clobazam belongs to the 1,5-benzodiazepine class of drugs and is expected to have a better side-effect profile compared to older 1,4-benzodiazepines. It has been marketed as an anxiolytic since 1975 and an anticonvulsant since 1984. The oral preparation was FDA approved on October 21, 2011. An oral suspension is expected to be available in 2013.
Indications and Usage For treatment and management of epilepsy and seizures associated with Lennox-Gastaut syndrome, a difficult-to-treat form of childhood epilepsy.
Marketing Status Prescription; Discontinued
ATC Code N05BA09
DrugBank ID DB00349
KEGG ID D01253
MeSH ID D000078306
PubChem ID 2789
TTD Drug ID D0S9MC
NDC Product Code 67386-313; 64330-110; 69766-016; 51672-4203; 0054-0561; 11014-0115; 82348-103; 72606-003; 69452-115; 42571-316; 67877-666; 51672-4210; 70710-1326; 51672-4202; 68180-157; 16714-087; 69238-1305; 51672-4227; 67877-665; 11014-0114; 69037-0009; 13632-313; 66689-058; 59651-401; 69238-1535; 0832-0585; 65085-0054; 70771-1441; 70710-1325; 47621-047; 67877-658; 69539-153; 67386-314; 68180-156; 0527-1681; 60687-423; 12828-0084; 68180-158; 31722-639; 31722-640; 10094-205; 69539-154; 70771-1440; 0832-0581; 16714-887; 72606-004; 0378-8043; 0832-0580; 42571-315; 69452-114; 0781-8013; 0054-0526; 51991-900; 51991-901; 42571-308; 0527-1682; 48087-0094; 10094-210; 0527-5301; 69238-1306; 69452-116; 16714-888; 67386-315; 0781-8014; 10094-220; 31722-641; 0054-0527; 48087-0117
Synonyms Clobazam | Urbanyl | Onfi | 1-Phenyl-5-methyl-8-chloro-1,2,4,5- tetrahydro-2,4-diketo-3H-1,5-benzodiazepine | HR 376 | LM-2717 | LM 2717 | LM2717 | Frisium
Chemical Information
Molecular Formula C16H13ClN2O2
CAS Registry Number 22316-47-8
SMILES CN1C(=O)CC(=O)N(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Affective disorder19.04.04.0010.001204%Not Available
Aggression19.05.01.0010.012642%Not Available
Agitation17.02.05.012; 19.06.02.0010.003913%
Alanine aminotransferase increased13.03.01.003--
Amenorrhoea05.05.01.002; 21.01.02.0010.000602%
Amnesia17.03.02.001; 19.20.01.0010.000903%
Anaemia01.03.02.001--
Anger19.04.02.0010.001505%Not Available
Angioedema10.01.05.009; 23.04.01.001--Not Available
Anterograde amnesia17.03.02.005; 19.20.01.005--Not Available
Anxiety19.06.02.002--
Apathy19.04.04.002--Not Available
Aspartate aminotransferase increased13.03.01.0060.000602%
Aspiration22.02.07.007--
Asthenia08.01.01.001--Not Available
Asthma10.01.03.010; 22.03.01.002--Not Available
Ataxia08.01.02.004; 17.02.02.0010.001204%
Blepharospasm06.05.01.001; 17.17.02.0010.000602%Not Available
Body temperature decreased13.15.01.0100.000903%Not Available
Body temperature increased13.15.01.001--Not Available
Bronchitis11.01.09.001; 22.07.01.0010.001204%
Cerebral atrophy17.11.01.0010.000602%Not Available
Cerebrovascular accident17.08.01.007; 24.03.05.001--
Chills08.01.09.001; 15.05.03.016--
Coma17.02.09.001--Not Available
Confusional state17.02.03.005; 19.13.01.0010.002107%
Constipation07.02.02.001--
Cough22.02.03.001--
Crying08.01.03.005; 12.02.11.001; 17.02.05.013; 19.04.02.0020.000602%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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