Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Thrombotic thrombocytopenic purpura
ADR ID BADD_A04288
ADR Hierarchy
24      Vascular disorders
24.07      Vascular haemorrhagic disorders
24.07.06      Bruising, ecchymosis and purpura
24.07.06.014      Thrombotic thrombocytopenic purpura
01      Blood and lymphatic system disorders
01.08      Platelet disorders
01.08.01      Thrombocytopenias
01.08.01.005      Thrombotic thrombocytopenic purpura
23      Skin and subcutaneous tissue disorders
23.06      Skin vascular abnormalities
23.06.01      Purpura and related conditions
23.06.01.011      Thrombotic thrombocytopenic purpura
Description A disorder characterized by the presence of microangiopathic hemolytic anemia, thrombocytopenic purpura, fever, renal abnormalities and neurological abnormalities such as seizures, hemiplegia, and visual disturbances. It is an acute or subacute condition. [CTCAE] An acquired, congenital, or familial disorder caused by PLATELET AGGREGATION with THROMBOSIS in terminal arterioles and capillaries. Clinical features include THROMBOCYTOPENIA; HEMOLYTIC ANEMIA; AZOTEMIA; FEVER; and thrombotic microangiopathy. The classical form also includes neurological symptoms and end-organ damage, such as RENAL FAILURE. Mutations in the ADAMTS13 PROTEIN gene have been identified in familial cases. [MeSH]
MedDRA Code 10043648
MeSH ID D011697
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Purpura thrombopaenic thrombotic | Purpura thrombopenic thrombotic | Thrombocytopenic purpura, thrombotic | Thrombotic thrombocytopenic purpura | TTP | Moschcowitz syndrome | Purpura, Thrombotic Thrombocytopenic | Thrombocytopenic Purpura, Thrombotic | Thrombotic Thrombocytopenic Purpura | Purpura, Thrombotic Thrombopenic | Thrombopenic Purpura, Thrombotic | Thrombotic Thrombopenic Purpura | Moschcowitz Disease | Moschkowitz Disease | Congenital Thrombotic Thrombocytopenic Purpura | Schulman-Upshaw Syndrome | Schulman Upshaw Syndrome | Upshaw-Schulman Syndrome | Upshaw Schulman Syndrome | Thrombotic Thrombocytopenic Purpura, Congenital | Upshaw Factor, Deficiency of | Microangiopathic Hemolytic Anemia, Congenital | Thrombotic Microangiopathy, Familial | Familial Thrombotic Microangiopathy | Microangiopathy, Familial Thrombotic | Familial Thrombotic Thrombocytopenic Purpura | Thrombotic Thrombocytopenic Purpura, Familial | Familial Thrombotic Thrombocytopenia Purpura
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00014Abiraterone0.000334%
BADD_D00032Acetylcysteine0.000149%
BADD_D00033Acetylsalicylic acid0.000022%
BADD_D00039Acyclovir0.000071%
BADD_D00047Afatinib0.000224%
BADD_D00142Anastrozole0.000477%
BADD_D00151Apixaban0.000130%
BADD_D00312Bupropion0.000046%
BADD_D00318Busulfan--
BADD_D00349Capecitabine0.000112%
BADD_D00367Carfilzomib0.000672%
BADD_D00412Cephalexin0.000017%
BADD_D00474Cisplatin0.000280%
BADD_D00504Clopidogrel0.000567%
BADD_D00505Clopidogrel bisulfate--
BADD_D00551Cyclosporine0.000111%
BADD_D00589Dasatinib0.000112%
BADD_D00653Diclofenac0.000115%
BADD_D00734Duloxetine0.000027%
BADD_D00760Eltrombopag olamine--
BADD_D00858Everolimus0.000153%
BADD_D00864Ezetimibe0.000063%
BADD_D00898Finasteride0.000112%
BADD_D00931Fluorouracil0.000276%
BADD_D00978Fulvestrant0.000334%
BADD_D00979Furosemide0.000028%
BADD_D01009Gemcitabine0.000224%
BADD_D01103Hydroxychloroquine0.001859%
BADD_D01157Infliximab--
BADD_D01167Interferon alfa-2b--
The 1th Page    1 2 3    Next   Last    Total 3 Pages