Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cisplatin
Drug ID BADD_D00474
Description Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.
Indications and Usage For the treatment of metastatic testicular tumors, metastatic ovarian tumors and advanced bladder cancer.
Marketing Status approved
ATC Code L01XA01
DrugBank ID DB00515
KEGG ID D00275
MeSH ID D002945
PubChem ID 5702198
TTD Drug ID D0U5HU
NDC Product Code 16729-288; 25021-253; 0143-9505; 68554-0077; 0143-9504; 68001-283; 44567-509; 50711-0001; 44567-510; 63323-103; 0703-5747; 0703-5748; 44567-530; 60505-6277; 68083-163; 44567-511; 49452-2078; 54875-0001; 67184-0010; 68083-162; 70860-206; 49812-0009; 72659-864
UNII Q20Q21Q62J
Synonyms Cisplatin | cis-Diamminedichloroplatinum(II) | Platinum Diamminodichloride | Diamminodichloride, Platinum | cis-Platinum | cis Platinum | Dichlorodiammineplatinum | cis-Diamminedichloroplatinum | cis Diamminedichloroplatinum | cis-Dichlorodiammineplatinum(II) | NSC-119875 | Platino | Platinol | Biocisplatinum | Platidiam
Chemical Information
Molecular Formula PtCl2(NH3)2
CAS Registry Number 15663-27-1
SMILES N.N.Cl[Pt]Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.0020.004600%
Abdominal pain lower07.01.05.0100.000336%-
Abdominal pain upper07.01.05.0030.001824%
Abdominal tenderness07.01.05.0040.000224%-
Acute hepatic failure09.01.03.0010.000616%-
Acute leukaemia01.10.02.001; 16.01.02.001---
Acute myeloid leukaemia01.10.05.001; 16.01.05.0010.000951%-
Acute myocardial infarction02.02.02.001; 24.04.04.0010.000448%-
Acute promyelocytic leukaemia01.10.05.003; 16.01.05.0030.000112%-
Acute pulmonary oedema02.05.02.004; 22.01.03.0050.000112%-
Acute respiratory distress syndrome10.02.01.067; 22.01.03.001; 24.03.02.0340.000728%
Acute respiratory failure14.01.04.004; 22.02.06.0010.000560%-
Adrenal insufficiency05.01.02.001; 14.11.01.0040.000112%
Ageusia07.14.03.003; 17.02.07.001---
Agranulocytosis01.02.03.0010.000895%-
Alopecia23.02.02.001--
Altered state of consciousness17.02.04.001; 19.07.01.0030.000672%-
Amylase increased13.05.01.009--
Anaemia01.03.02.0010.008988%
Anaphylactic shock10.01.07.002; 24.06.02.0040.000336%-
Antidiuretic hormone abnormality05.03.03.005; 14.05.07.0040.000112%-
Anuria20.01.03.0020.000280%-
Aortic aneurysm24.02.03.0010.000168%-
Aortic stenosis24.04.01.0010.000302%-
Aortic thrombosis24.01.09.0010.000672%-
Apathy19.04.04.0020.000168%-
Aphasia17.02.03.001; 19.21.01.0010.000280%
Aphthous ulcer07.05.06.0020.000112%-
Aptyalism07.06.01.0010.000112%-
Arterial thrombosis24.01.01.0020.000560%-
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ADReCS-Target
Drug Name ADR Term Target
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