Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Hepatic encephalopathy
ADR ID BADD_A01999
ADR Hierarchy
17      Nervous system disorders
17.13      Encephalopathies
17.13.01      Encephalopathies toxic and metabolic
17.13.01.003      Hepatic encephalopathy
09      Hepatobiliary disorders
09.01      Hepatic and hepatobiliary disorders
09.01.03      Hepatic failure and associated disorders
09.01.03.006      Hepatic encephalopathy
Description A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5) [MeSH]
MedDRA Code 10019660
MeSH ID D006501
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Encephalopathy hepatic | Hepatic encephalopathy | Minimal hepatic encephalopathy | Hepatic encephalopathy stage 3 | Hepatic encephalopathy stage 2 | Hepatic encephalopathy stage 1 | Hepatic encephalopathy stage 4 | Hepatic Encephalopathy | Encephalopathies, Hepatic | Hepatic Encephalopathies | Encephalopathy, Hepatic | Portal-Systemic Encephalopathy | Portal Systemic Encephalopathy | Encephalopathy, Portal-Systemic | Encephalopathies, Portal-Systemic | Encephalopathy, Portal Systemic | Portal-Systemic Encephalopathies | Encephalopathy, Portosystemic | Hepatocerebral Encephalopathy | Portosystemic Encephalopathy | Encephalopathies, Portosystemic | Portosystemic Encephalopathies | Encephalopathy, Hepatocerebral | Encephalopathies, Hepatocerebral | Hepatocerebral Encephalopathies | Hepatic Coma | Coma, Hepatic | Comas, Hepatic | Hepatic Comas | Hepatic Stupor | Hepatic Stupors | Stupor, Hepatic | Stupors, Hepatic | Fulminant Hepatic Failure with Cerebral Edema
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00931Fluorouracil0.000184%
BADD_D00943Flutamide--
BADD_D00979Furosemide0.000090%
BADD_D01081Hydralazine0.000068%
BADD_D01103Hydroxychloroquine0.002789%
BADD_D01135Iloprost0.000082%
BADD_D01136Imatinib0.000638%
BADD_D01149Indapamide--
BADD_D01167Interferon alfa-2b--
BADD_D01168Interferon alfacon-1--
BADD_D01204Isoniazid0.020014%
BADD_D01238Lacosamide0.001463%
BADD_D01240Lactulose0.000805%
BADD_D01242Lamivudine0.001518%
BADD_D01252Leflunomide0.000428%
BADD_D01253Lenalidomide--
BADD_D01254Lenvatinib0.014428%
BADD_D01271Levocarnitine0.004312%
BADD_D01292Linagliptin--
BADD_D01318Lorazepam0.000114%
BADD_D01336Macitentan0.001083%
BADD_D01392Mercaptopurine0.002082%
BADD_D01393Meropenem0.000122%
BADD_D01414Methimazole0.000202%
BADD_D01418Methotrexate--
BADD_D01425Methyldopa0.001027%
BADD_D01433Methylprednisolone0.000032%
BADD_D01470Minocycline0.000118%
BADD_D01558Nexium--
BADD_D01572Nitisinone0.006469%
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