Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Extrapyramidal disorder
ADR ID BADD_A01568
ADR Hierarchy
17      Nervous system disorders
17.01      Movement disorders (incl parkinsonism)
17.01.02      Dyskinesias and movement disorders NEC
17.01.02.007      Extrapyramidal disorder
Description A disorder characterized by abnormal, repetitive, involuntary muscle movements, frenzied speech and extreme restlessness. [CTCAE] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (most notably involuntary movements and alterations of the rate of movement) represent the primary clinical manifestations of these disorders. Common etiologies include CEREBROVASCULAR DISORDERS; NEURODEGENERATIVE DISEASES; and CRANIOCEREBRAL TRAUMA. [MeSH]
MedDRA Code 10015832
MeSH ID D001480
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Benign shuddering attacks | Drug-induced extrapyramidal side effects | Extrapyramidal disorder | Extrapyramidal disorder (NOS) | Extrapyramidal disorder NEC | Extrapyramidal symptoms | Extrapyramidal syndrome | Extrapyramidal syndrome (NOS) | Other and unspecified extrapyramidal diseases and abnormal movement disorders | Other extrapyramidal disease and abnormal movement disorders | Other extrapyramidal diseases and abnormal movement disorders | Syndrome extrapyramidal | Unspecified extrapyramidal disease and abnormal movement disorder | Extrapyramidal disorder aggravate | Extrapyramidal disorder aggravated | Basal Ganglia Diseases | Basal Ganglia Disease | Basal Ganglia Disorders | Basal Ganglia Disorder | Extrapyramidal Disorders | Extrapyramidal Disorder | Lenticulostriate Disorders | Lenticulostriate Disorder
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01737Perhexiline--
BADD_D01743Perphenazine--
BADD_D01765Phenytoin--
BADD_D01774Pimozide--
BADD_D01817Pramipexole--
BADD_D01818Pramipexole dihydrochloride--
BADD_D01835Pregabalin--
BADD_D01848Prochlorperazine0.000536%
BADD_D01849Prochlorperazine edisylate--
BADD_D01850Prochlorperazine maleate--
BADD_D01854Promethazine--
BADD_D01855Promethazine hydrochloride--
BADD_D01872Protriptyline--
BADD_D01873Protriptyline hydrochloride--
BADD_D01888Quetiapine0.001052%
BADD_D01889Quetiapine fumarate--
BADD_D01898Rabeprazole--
BADD_D01926Reserpine--
BADD_D01942Riluzole--
BADD_D01951Risperidone0.024076%
BADD_D01955Rivastigmine0.000813%
BADD_D01956Rivastigmine tartrate--
BADD_D01966Ropinirole--
BADD_D02010Sertraline0.000199%
BADD_D02011Sertraline hydrochloride--
BADD_D02098Sumatriptan--
BADD_D02104Tacrine hydrochloride--
BADD_D02148Temazepam--
BADD_D02150Temozolomide--
BADD_D02175Tetrabenazine--
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ADReCS-Target
ADR Term Drug Name Target