Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tacrine hydrochloride
Drug ID BADD_D02104
Description A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market.
Indications and Usage For the palliative treatment of mild to moderate dementia of the Alzheimer's type.
Marketing Status Discontinued
ATC Code N06DA01
DrugBank ID DB00382
KEGG ID D02068
MeSH ID D013619
PubChem ID 2723754
TTD Drug ID D0E6YQ
NDC Product Code Not Available
Synonyms Tacrine | 9-Amino-1,2,3,4-Tetrahydroacridine | 1,2,3,4-Tetrahydro-9-acridinamine | Tetrahydroaminoacridine | 1,2,3,4-Tetrahydroaminoacridine | Romotal | Tenakrin | THA | Cognex | Tacrine Hydrochloride
Chemical Information
Molecular Formula C13H15ClN2
CAS Registry Number 1684-40-8
SMILES C1CCC2=NC3=CC=CC=C3C(=C2C1)N.Cl
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abnormal dreams17.15.02.001; 19.02.03.001--Not Available
Acne23.02.01.001--Not Available
Agitation17.02.05.012; 19.06.02.001--
Akathisia17.01.02.002; 19.06.02.006--
Alopecia23.02.02.001--
Amblyopia06.02.01.001--Not Available
Amnesia17.03.02.001; 19.20.01.001--
Anaemia01.03.02.001--
Angina pectoris02.02.02.002; 24.04.04.002--
Anxiety19.06.02.002--
Aortic aneurysm24.02.03.001--Not Available
Apathy19.04.04.002--Not Available
Aphasia17.02.03.001; 19.21.01.001--
Apraxia17.02.03.002; 19.21.01.002--Not Available
Areflexia17.02.01.001--Not Available
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Asthenia08.01.01.001--Not Available
Asthma10.01.03.010; 22.03.01.002--Not Available
Ataxia08.01.02.004; 17.02.02.001--
Atrial fibrillation02.03.03.002--
Atrial flutter02.03.03.003--
Atrioventricular block02.03.01.002--Not Available
Back pain15.03.04.005--
Basal cell carcinoma16.03.02.001; 23.08.02.001--Not Available
Bladder neoplasm16.08.03.002; 20.03.04.002--Not Available
Blepharitis06.04.04.001; 23.03.04.012--Not Available
Blindness06.02.02.001; 17.17.01.003--Not Available
Bradycardia02.03.02.002--Not Available
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