Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Disseminated intravascular coagulation
ADR ID BADD_A01304
ADR Hierarchy
01      Blood and lymphatic system disorders
01.01      Coagulopathies and bleeding diatheses (excl thrombocytopenic)
01.01.02      Coagulopathies
01.01.02.002      Disseminated intravascular coagulation
24      Vascular disorders
24.01      Embolism and thrombosis
24.01.01      Non-site specific embolism and thrombosis
24.01.01.010      Disseminated intravascular coagulation
Description A disorder characterized by systemic pathological activation of blood clotting mechanisms which results in clot formation throughout the body. There is an increase in the risk of hemorrhage as the body is depleted of platelets and coagulation factors. [CTCAE] A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS. [MeSH]
MedDRA Code 10013442
MeSH ID D004211; D003606
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Consumption coagulopathy | Consumptive coagulopathy | Defibrination syndrome | DIC | Dissem. intravasc. coagulation | Disseminated intravacular coagulation | Disseminated intravascular coagulation | Systemic hypercoagulative disorder | Consumptive thrombohaemorrhagic syndrome | Consumptive thrombohemorrhagic syndrome | Disseminated Intravascular Coagulation | Disseminated Coagulation, Intravascular | Coagulation, Intravascular Disseminated | Coagulations, Intravascular Disseminated | Disseminated Coagulations, Intravascular | Intravascular Disseminated Coagulations | Intravascular Coagulation, Disseminated | Intravascular Disseminated Coagulation | Coagulation, Disseminated Intravascular | Coagulations, Disseminated Intravascular | Disseminated Intravascular Coagulations | Intravascular Coagulations, Disseminated | Consumption Coagulopathy | Coagulopathies, Consumption | Coagulopathy, Consumption | Consumption Coagulopathies
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00706Donepezil0.000070%
BADD_D00723Doxorubicin0.000168%
BADD_D00773Entacapone0.004115%
BADD_D00775Enzalutamide0.001001%
BADD_D00784Epirubicin0.000246%
BADD_D00792Eptifibatide0.000082%
BADD_D00798Eribulin0.000336%
BADD_D00843Ethanolamine oleate--
BADD_D00854Etoposide0.000280%
BADD_D00858Everolimus0.000841%
BADD_D00869Famotidine0.000045%
BADD_D00871Felbamate--
BADD_D00931Fluorouracil0.000276%
BADD_D00956Fomepizole--
BADD_D00979Furosemide0.000035%
BADD_D00984Gadobutrol0.010670%
BADD_D01009Gemcitabine0.000168%
BADD_D01015Gemtuzumab ozogamicin--
BADD_D01023Glimepiride0.000042%
BADD_D01086Hydrocortisone0.000046%
BADD_D01110Hydroxyurea0.000280%
BADD_D01133Ifosfamide--
BADD_D01136Imatinib0.000672%
BADD_D01156Indomethacin--
BADD_D01178Iodixanol--
BADD_D01184Iothalamic acid--
BADD_D01186Ioversol--
BADD_D01188Ioxaglic acid--
BADD_D01195Irinotecan0.000168%
BADD_D01204Isoniazid0.004170%
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