Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Epirubicin
Drug ID BADD_D00784
Description An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.
Indications and Usage For use as a component of adjuvant therapy in patients with evidence of axillary node tumor involvement following resection of primary breast cancer.
Marketing Status Prescription; Discontinued
ATC Code L01DB03
DrugBank ID DB00445
KEGG ID D07901
MeSH ID D015251
PubChem ID 41867
TTD Drug ID D0C9XJ
NDC Product Code Not Available
Synonyms Epirubicin | 4'-Epidoxorubicin | 4' Epidoxorubicin | 4'-Epi-Doxorubicin | 4' Epi Doxorubicin | 4'-Epi-Adriamycin | 4' Epi Adriamycin | 4'-Epiadriamycin | 4' Epiadriamycin | 4'-Epi-DXR | 4' Epi DXR | EPI-cell | EPI cell | EPIcell | Epilem | Farmorubicina | IMI-28 | IMI 28 | IMI28 | NSC-256942 | NSC 256942 | NSC256942 | Ellence | Pharmorubicin | Farmorubicine | Farmorubicin | Epirubicin Hydrochloride | Hydrochloride, Epirubicin
Chemical Information
Molecular Formula C27H29NO11
CAS Registry Number 56420-45-2
SMILES CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.0020.000533%
Abdominal pain upper07.01.05.0030.001066%
Acute lymphocytic leukaemia01.10.01.001; 16.01.01.001--Not Available
Agranulocytosis01.02.03.001--Not Available
Alopecia23.02.02.0010.001332%
Amenorrhoea05.05.01.002; 21.01.02.001--
Anaemia01.03.02.0010.000533%
Anaphylactic shock10.01.07.002; 24.06.02.004--Not Available
Anuria20.01.03.002--Not Available
Aphthous ulcer07.05.06.0020.000533%Not Available
Aplastic anaemia01.03.03.002--Not Available
Arrhythmia02.03.02.001--Not Available
Ascites02.05.04.002; 07.07.01.001; 09.01.05.003--
Asthenia08.01.01.0010.000799%Not Available
Atrioventricular block02.03.01.002--Not Available
Azoospermia21.03.03.001--
Bacteraemia11.01.11.0010.000533%
Bladder stenosis20.03.01.011--Not Available
Blister12.01.06.002; 23.03.01.001--Not Available
Blood lactate dehydrogenase increased13.04.02.002--
Blood pressure increased13.14.03.0050.000533%Not Available
Blood uric acid increased13.02.04.001--Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Breast cancer16.10.01.001; 21.05.01.0030.000533%Not Available
Bundle branch block02.03.01.009--Not Available
Burning sensation08.01.09.029; 17.02.06.001--Not Available
Cardiac failure02.05.01.0010.000208%
Cardiac failure congestive02.05.01.002--Not Available
Cardiomegaly02.04.02.001--Not Available
The 1th Page    1 2 3 4 5    Next   Last    Total 6 Pages
ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene