| Drug Name |
Progesterone |
| Drug ID |
BADD_D01852 |
| Description |
Progesterone is a hormone that occurs naturally in females, and is essential for endometrial receptivity, embryo implantation, and the successful establishment of pregnancy. A low progesterone concentration or an insufficient response to progesterone can cause infertility and pregnancy loss [A175609]. Progesterone is used in various contraceptive preparations to prevent ovulation and fertilization [T481], [A175612] as well as in other formulations to promote and support pregnancy. Please see [Medroxyprogesterone acetate], [Megestrol acetate], [Dydrogesterone] and [Hydroxyprogesterone] entries for information on various other forms of progesterone.
Pharmaceutical progesterone is made from a plant source as a starting material and is chemically identical to progesterone of human ovarian origin [FDA label]. Progesterone is available in gelatinized capsule form, vaginal gel form, tablet form, vaginal insert form, and injection form, all used for various purposes [Label,F3898,F3904,F3901,F3907]. |
| Indications and Usage |
**Gelatinized capsules**
The gelatinized capsules are indicated for use in the prevention of endometrial hyperplasia in non-hysterectomized postmenopausal women who are receiving conjugated estrogens tablets. They are also indicated for use in secondary amenorrhea [FDA label].
**Vaginal gel**
Progesterone gel (8%) is indicated as progesterone supplementation or replacement as part of an Assisted Reproductive Technology (“ART”) treatment for infertile women with progesterone deficiency. The lower concentration progesterone gel (4%) is used in the treatment of secondary amenorrhea, with the use of the 8% concentration if there is no therapeutic response to the 4% gel [F3898].
**Vaginal insert**
This form is indicated to support embryo implantation and early pregnancy by supplementation of corpus luteal function as part of an Assisted Reproductive Technology (ART) treatment program for infertile women [F3901].
**Injection (intramuscular)**
This drug is indicated in amenorrhea and abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology, such as submucous fibroids or uterine cancer [F3907].
**Tablets, contraceptive**
The tablet form of progesterone in contraceptive formulations is indicated for the prevention of pregnancy [F3904]. |
| Marketing Status |
approved; vet_approved |
| ATC Code |
G03DA04 |
| DrugBank ID |
DB00396
|
| KEGG ID |
D00066
|
| MeSH ID |
D011374
|
| PubChem ID |
5994
|
| TTD Drug ID |
D07BSQ
|
| NDC Product Code |
72989-373; 76420-267; 76420-282; 22552-0049; 38779-0043; 38779-0057; 49452-6079; 51552-1248; 51927-5124; 62991-1124; 77382-0030; 43857-0120; 55150-306; 55714-9004; 59651-152; 69452-234; 71205-684; 71335-1913; 72189-217; 0009-5023; 16637-0040; 38779-3247; 43647-134; 51552-1279; 68981-005; 43598-350; 50090-5928; 55566-6500; 63629-7475; 65162-807; 68071-2770; 70518-3286; 0591-3128; 71335-1432; 71335-1443; 71335-1990; 72189-204; 76420-059; 11014-0042; 11014-0043; 43598-349; 48087-0057; 51508-007; 51927-1046; 82393-102; 43857-0103; 63083-1538; 69452-233; 69543-374; 65162-808; 68071-2832; 69543-372; 69543-375; 71205-902; 71205-903; 76420-058; 0009-0105; 10888-8109; 11014-0425; 51552-0006; 51552-1066; 51927-0009; 44911-0047; 69452-149; 69543-373; 71205-293; 0009-0052; 10888-8110; 11014-0039; 51552-0738; 51927-9017; 64025-9801; 76420-682; 79572-029; 59651-153; 69452-148; 71335-0835; 72189-347; 76420-072; 0009-5620; 48087-0105; 51552-0829; 60870-0248; 77382-0140; 16714-158; 43742-0851; 63629-8530; 70518-3392; 70700-163; 71205-669; 71335-9739; 76420-073; 76420-281; 0009-0081; 12875-9937; 51508-002; 60592-607; 43857-0084; 68788-8296; 70700-162; 70700-286; 76420-574; 11014-0189; 12875-9242; 16637-0030; 38779-0310; 38779-2708; 38779-3169; 46144-101; 73309-164; 16714-157; 0023-6150; 63323-261; 68071-2768; 68071-2840; 68788-8295; 70518-2560; 71335-1406; 82653-003; 11014-0051; 43742-1375; 49452-6061; 60722-3010; 73377-048; 75882-923; 76420-683; 77382-0050; 0143-9725; 50090-6475; 0023-6151; 72989-372; 82653-004; 83027-0073; 0009-0078 |
| UNII |
4G7DS2Q64Y
|
| Synonyms |
Progesterone | Pregnenedione | Progesterone, (17 alpha)-Isomer | Progesterone, (9 beta,10 alpha)-Isomer | Progesterone, (13 alpha,17 alpha)-(+-)-Isomer |
