Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Progesterone
Drug ID BADD_D01852
Description Progesterone is a hormone that occurs naturally in females, and is essential for endometrial receptivity, embryo implantation, and the successful establishment of pregnancy. A low progesterone concentration or an insufficient response to progesterone can cause infertility and pregnancy loss [A175609]. Progesterone is used in various contraceptive preparations to prevent ovulation and fertilization [T481], [A175612] as well as in other formulations to promote and support pregnancy. Please see [Medroxyprogesterone acetate], [Megestrol acetate], [Dydrogesterone] and [Hydroxyprogesterone] entries for information on various other forms of progesterone. Pharmaceutical progesterone is made from a plant source as a starting material and is chemically identical to progesterone of human ovarian origin [FDA label]. Progesterone is available in gelatinized capsule form, vaginal gel form, tablet form, vaginal insert form, and injection form, all used for various purposes [Label,F3898,F3904,F3901,F3907].
Indications and Usage **Gelatinized capsules** The gelatinized capsules are indicated for use in the prevention of endometrial hyperplasia in non-hysterectomized postmenopausal women who are receiving conjugated estrogens tablets. They are also indicated for use in secondary amenorrhea [FDA label]. **Vaginal gel** Progesterone gel (8%) is indicated as progesterone supplementation or replacement as part of an Assisted Reproductive Technology (“ART”) treatment for infertile women with progesterone deficiency. The lower concentration progesterone gel (4%) is used in the treatment of secondary amenorrhea, with the use of the 8% concentration if there is no therapeutic response to the 4% gel [F3898]. **Vaginal insert** This form is indicated to support embryo implantation and early pregnancy by supplementation of corpus luteal function as part of an Assisted Reproductive Technology (ART) treatment program for infertile women [F3901]. **Injection (intramuscular)** This drug is indicated in amenorrhea and abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology, such as submucous fibroids or uterine cancer [F3907]. **Tablets, contraceptive** The tablet form of progesterone in contraceptive formulations is indicated for the prevention of pregnancy [F3904].
Marketing Status approved; vet_approved
ATC Code G03DA04
DrugBank ID DB00396
KEGG ID D00066
MeSH ID D011374
PubChem ID 5994
TTD Drug ID D07BSQ
NDC Product Code 72989-373; 76420-267; 76420-282; 22552-0049; 38779-0043; 38779-0057; 49452-6079; 51552-1248; 51927-5124; 62991-1124; 77382-0030; 43857-0120; 55150-306; 55714-9004; 59651-152; 69452-234; 71205-684; 71335-1913; 72189-217; 0009-5023; 16637-0040; 38779-3247; 43647-134; 51552-1279; 68981-005; 43598-350; 50090-5928; 55566-6500; 63629-7475; 65162-807; 68071-2770; 70518-3286; 0591-3128; 71335-1432; 71335-1443; 71335-1990; 72189-204; 76420-059; 11014-0042; 11014-0043; 43598-349; 48087-0057; 51508-007; 51927-1046; 82393-102; 43857-0103; 63083-1538; 69452-233; 69543-374; 65162-808; 68071-2832; 69543-372; 69543-375; 71205-902; 71205-903; 76420-058; 0009-0105; 10888-8109; 11014-0425; 51552-0006; 51552-1066; 51927-0009; 44911-0047; 69452-149; 69543-373; 71205-293; 0009-0052; 10888-8110; 11014-0039; 51552-0738; 51927-9017; 64025-9801; 76420-682; 79572-029; 59651-153; 69452-148; 71335-0835; 72189-347; 76420-072; 0009-5620; 48087-0105; 51552-0829; 60870-0248; 77382-0140; 16714-158; 43742-0851; 63629-8530; 70518-3392; 70700-163; 71205-669; 71335-9739; 76420-073; 76420-281; 0009-0081; 12875-9937; 51508-002; 60592-607; 43857-0084; 68788-8296; 70700-162; 70700-286; 76420-574; 11014-0189; 12875-9242; 16637-0030; 38779-0310; 38779-2708; 38779-3169; 46144-101; 73309-164; 16714-157; 0023-6150; 63323-261; 68071-2768; 68071-2840; 68788-8295; 70518-2560; 71335-1406; 82653-003; 11014-0051; 43742-1375; 49452-6061; 60722-3010; 73377-048; 75882-923; 76420-683; 77382-0050; 0143-9725; 50090-6475; 0023-6151; 72989-372; 82653-004; 83027-0073; 0009-0078
UNII 4G7DS2Q64Y
Synonyms Progesterone | Pregnenedione | Progesterone, (17 alpha)-Isomer | Progesterone, (9 beta,10 alpha)-Isomer | Progesterone, (13 alpha,17 alpha)-(+-)-Isomer
Chemical Information
Molecular Formula C21H30O2
CAS Registry Number 57-83-0
SMILES CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Jugular vein thrombosis24.01.02.0070.000125%-
Cholestasis of pregnancy09.01.01.013; 18.02.04.0030.000251%-
Live birth18.08.02.0070.000314%-
Carotid artery dissection17.08.06.003; 24.02.04.0040.000125%-
Embolia cutis medicamentosa08.02.03.052; 12.07.03.052; 24.01.01.0300.000125%-
Choroidal neovascularisation06.10.03.004; 24.03.07.0110.000125%-
Embolic cerebral infarction17.08.01.029; 24.01.04.0090.000125%-
Foetal hypokinesia18.03.02.0150.000125%-
Autoimmune dermatitis10.04.02.012; 23.03.04.0370.000439%-
Biochemical pregnancy18.02.02.0180.000125%-
Decidual cast18.02.02.019; 21.07.01.0230.000125%-
Graves' disease05.02.02.009; 06.09.04.009; 10.04.08.014---
Heavy menstrual bleeding21.01.03.0050.000125%-
Idiopathic angioedema10.01.05.023; 23.04.01.0230.000125%-
Intermenstrual bleeding21.01.01.0150.000427%-
Lactation insufficiency18.06.02.006; 21.05.02.0060.000125%-
Malignant nervous system neoplasm16.30.03.003; 17.20.03.0030.000314%-
Reaction to excipient10.01.01.0420.000125%-
Therapeutic product effect decreased08.06.01.0500.000276%-
Therapeutic product effect incomplete08.06.01.052---
Tolosa-Hunt syndrome06.05.02.031; 17.04.01.0070.000125%-
Treatment noncompliance08.06.01.067; 12.09.02.006---
Twin pregnancy18.08.03.0020.000125%-
Vulvovaginal inflammation21.14.02.014---
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ADReCS-Target
Drug Name ADR Term Target
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