Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pamidronic acid
Drug ID BADD_D01662
Description Pamidronic acid is a second generation, nitrogen containing bisphosphonate similar to [neridronic acid] and [alendronic acid].[A203111] Pamidronic acid was first described in the literature in 1977.[A203267] The second generation bisphosphonates are less common as third generation bisphosphonates, such as [ibandronic acid], [zoledronic acid], [minodronic acid], and [risedronic acid] are becoming more popular.[A203111] Pamidronic acid was granted FDA approval on 31 October 1991.[L13835]
Indications and Usage Pamidronate is indicated to treat moderate to severe hypercalcemia of malignancy, moderate to severe Paget's disease of bone, osteolytic bone metastases of breast cancer, and osteolytic lesions of multiple myeloma.[L13838]
Marketing Status approved
ATC Code M05BA03
DrugBank ID DB00282
KEGG ID D07281
MeSH ID D000077268
PubChem ID 4674
TTD Drug ID D0BF8G
NDC Product Code 53104-7611; 50711-0003
UNII OYY3447OMC
Synonyms Pamidronate | Amino-1-hydroxypropane-1,1-diphosphonate | Amino 1 hydroxypropane 1,1 diphosphonate | AHPrBP | Aminopropanehydroxydiphosphonate | Amidronate | (3-Amino-1-hydroxypropylidene)-1,1-biphosphonate | Aminohydroxypropylidene Diphosphonate | 1-Hydroxy-3-aminopropane-1,1-diphosphonic acid | 1 Hydroxy 3 aminopropane 1,1 diphosphonic acid | Pamidronic Acid | Pamidronate Monosodium | Pamidronate Calcium | Pamidronate Disodium | Aredia
Chemical Information
Molecular Formula C3H11NO7P2
CAS Registry Number 40391-99-9
SMILES C(CN)C(O)(P(=O)(O)O)P(=O)(O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Ill-defined disorder08.01.03.049---
Blood disorder01.05.01.004---
Chondrocalcinosis14.04.01.017; 15.01.06.0060.000126%-
Disease recurrence08.01.03.050---
Drug intolerance08.06.01.0130.000340%-
Psychotic disorder19.03.01.002--
Metastasis16.22.01.001---
Renal impairment20.01.03.0100.000189%-
Cholecystitis infective09.03.01.006; 11.01.18.002--
Hypophagia07.01.06.010; 14.03.01.006; 19.09.01.0040.000252%-
Osteonecrosis of jaw15.02.04.010; 24.04.05.0050.002141%
Infusion site thrombosis08.02.05.006; 12.07.05.007; 24.01.01.0220.000189%-
Oral disorder07.05.01.005---
Focal segmental glomerulosclerosis20.05.01.0030.000126%-
Acute kidney injury20.01.03.016--
Langerhans' cell histiocytosis01.13.04.003; 09.01.08.018; 15.09.03.008; 16.21.04.003; 22.01.01.016---
Candida infection11.03.03.021--
Bone cancer15.09.03.012; 16.29.02.002---
Metastases to bone15.09.03.006; 16.22.02.005---
Bone formation decreased15.02.04.0280.000189%-
Deformity08.01.03.0220.000315%-
Weight bearing difficulty15.03.05.0340.000126%-
Metastases to pelvis16.22.02.021; 21.07.04.008---
Drug ineffective for unapproved indication08.06.01.038; 12.09.02.0020.001033%-
Illness08.01.03.091---
Joint noise15.01.02.012---
Mineral metabolism disorder14.13.04.0020.000189%-
Product administration error12.09.03.003---
Superficial vein thrombosis24.01.02.0160.000126%-
Therapy non-responder08.06.01.0630.000277%-
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