Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nortriptyline
Drug ID BADD_D01588
Description Nortriptyline hydrochloride, the active metabolite of [amitriptyline], is a tricyclic antidepressant (TCA).[L11878] It is used in the treatment of major depression and is also used off-label for chronic pain and other conditions.[L11881]
Indications and Usage Nortriptyline is indicated for the relief of the symptoms of major depressive disorder (MDD).[L11878] Some off-label uses for this drug include treatment of chronic pain, myofascial pain, neuralgia, and irritable bowel syndrome.[A191083,L11878]
Marketing Status approved
ATC Code N06AA10
DrugBank ID DB00540
KEGG ID D08288
MeSH ID D009661
PubChem ID 4543
TTD Drug ID D04WFD
NDC Product Code Not Available
UNII BL03SY4LXB
Synonyms Nortriptyline | Desitriptyline | Desmethylamitriptylin | Allegron | Apo-Nortriptyline | Apo Nortriptyline | Aventyl | Gen-Nortriptyline | Gen Nortriptyline | Paxtibi | Nortrilen | Nortriptyline Hydrochloride | Hydrochloride, Nortriptyline | Novo-Nortriptyline | Novo Nortriptyline | Nu-Nortriptyline | Nu Nortriptyline | Pamelor | PMS-Nortriptyline | PMS Nortriptyline | ratio-Nortriptyline | ratio Nortriptyline | Norfenazin
Chemical Information
Molecular Formula C19H21N
CAS Registry Number 72-69-5
SMILES CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Depressed level of consciousness17.02.04.0020.000119%
Dermatitis23.03.04.002---
Dermatitis allergic10.01.03.014; 23.03.04.003---
Dermatitis atopic10.01.04.004; 23.03.04.016---
Diarrhoea07.02.01.001--
Discomfort08.01.08.003---
Disorientation17.02.05.015; 19.13.01.002---
Disturbance in attention17.03.03.001; 19.21.02.002--
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Drug abuse19.07.06.0100.000297%-
Drug hypersensitivity10.01.01.0010.000605%-
Drug ineffective08.06.01.0060.001009%-
Drug withdrawal syndrome08.06.02.004; 19.07.06.013---
Dry mouth07.06.01.002--
Dysgeusia07.14.03.001; 17.02.07.003--
Dyspepsia07.01.02.001--
Dysphagia07.01.06.0030.001068%
Dyspnoea02.11.05.003; 22.02.01.004--
Electrocardiogram QRS complex13.14.05.034---
Electrocardiogram QT prolonged13.14.05.004--
Eosinophilia01.02.04.001--
Extrapyramidal disorder17.01.02.007--
Eye disorder06.08.03.001---
Eye pain06.08.03.002--
Face oedema08.01.07.003; 10.01.05.002; 23.04.01.004--
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014---
Flushing08.01.03.025; 23.06.05.003; 24.03.01.002--
Galactorrhoea05.03.04.002; 21.05.02.002---
Gingivitis07.09.10.002; 11.01.04.013--
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ADReCS-Target
Drug Name ADR Term Target
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