Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clomiphene
Drug ID BADD_D00497
Description A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue.
Indications and Usage Used mainly in female infertility due to anovulation (e.g. due to polycystic ovary syndrome) to induce ovulation.
Marketing Status approved; investigational
ATC Code G03GB02
DrugBank ID DB00882
KEGG ID D07726
MeSH ID D002996
PubChem ID 1548953
TTD Drug ID D0CT9Y
NDC Product Code Not Available
UNII 1HRS458QU2
Synonyms Clomiphene | Clomifene | Chloramiphene | Clomifen | Clomiphene Citrate | Citrate, Clomiphene | Clomiphene Hydrochloride | Hydrochloride, Clomiphene | Serophene | Gravosan | Klostilbegit | Clostilbegit | Clomid | Clomide | Dyneric
Chemical Information
Molecular Formula C26H28ClNO
CAS Registry Number 15690-57-0
SMILES CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Leukaemia01.10.03.001; 16.01.03.001--
Leukocytosis01.02.01.002--
Limb reduction defect03.11.07.004; 15.11.07.004---
Liver disorder09.01.08.001---
Loss of consciousness17.02.04.004---
Lymphocytic leukaemia01.10.09.001; 16.01.09.001---
Macular oedema06.04.06.005---
Malignant melanoma16.03.01.001; 23.08.01.001---
Meningomyelocele03.10.02.006; 17.19.01.006---
Menopausal symptoms21.02.02.002---
Mental disability26.01.01.001---
Microcephaly03.11.02.002; 15.11.02.002---
Migraine17.14.02.001; 24.03.05.003---
Mood swings19.04.03.001---
Multiple pregnancy18.08.03.001---
Myalgia15.05.02.001--
Myopathy15.05.05.001---
Nausea07.01.07.001--
Neoplasm16.16.02.001---
Nervousness19.06.02.003---
Neurofibromatosis03.10.01.002; 16.09.01.002; 17.18.01.002; 23.05.01.018---
Oedema08.01.07.006; 14.05.06.010---
Optic neuritis06.04.08.002; 10.02.01.097; 17.04.05.001---
Ovarian cancer16.12.04.001; 21.11.01.003---
Ovarian cyst16.04.03.001; 21.11.01.002---
Ovarian enlargement21.11.02.001---
Ovarian germ cell teratoma benign16.04.03.002; 21.11.01.004---
Ovarian hyperstimulation syndrome05.05.01.013; 21.11.02.007---
Ovulation pain21.01.01.016--
Pain08.01.08.004--
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