Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Ovarian hyperstimulation syndrome
ADR ID BADD_A03244
ADR Hierarchy
21      Reproductive system and breast disorders
21.11      Ovarian and fallopian tube disorders
21.11.02      Ovarian and fallopian tube disorders NEC
21.11.02.007      Ovarian hyperstimulation syndrome
05      Endocrine disorders
05.05      Endocrine disorders of gonadal function
05.05.01      Female gonadal function disorders
05.05.01.013      Ovarian hyperstimulation syndrome
Description A complication of OVULATION INDUCTION in infertility treatment. It is graded by the severity of symptoms which include OVARY enlargement, multiple OVARIAN FOLLICLES; OVARIAN CYSTS; ASCITES; and generalized EDEMA. The full-blown syndrome may lead to RENAL FAILURE, respiratory distress, and even DEATH. Increased capillary permeability is caused by the vasoactive substances, such as VASCULAR ENDOTHELIAL GROWTH FACTORS, secreted by the overly-stimulated OVARIES. [MeSH]
MedDRA Code 10033266
MeSH ID D016471
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Ovarian hyperstimulation | Ovarian hyperstimulation syndrome | Threatened ovarian hyperstimulation syndrome | Ovarian Hyperstimulation Syndrome | Hyperstimulation Syndrome, Ovarian | Hyperstimulation Syndromes, Ovarian | Ovarian Hyperstimulation Syndromes | Ovarian Hyperstimulation Syndrome, Familial Gestational Spontaneous
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00033Acetylsalicylic acid0.000022%
BADD_D00144Antagon--
BADD_D00329Cabergoline0.033631%
BADD_D00420Cetrorelix acetate--
BADD_D00421Cetrorelix trifluoroacetate--
BADD_D00457Choriogonadotropin alfa--
BADD_D00497Clomiphene--
BADD_D00623Dexamethasone0.000145%
BADD_D00821Estradiol0.000062%
BADD_D00953Follitropin--
BADD_D00954Follitropin alfa--
BADD_D00955Follitropin beta--
BADD_D01005Ganirelix acetate--
BADD_D01036Gonadorelin--
BADD_D01038Goserelin--
BADD_D01257Letrozole0.006638%
BADD_D01260Leuprolide acetate0.010038%
BADD_D01332Lutropin alfa--
BADD_D01380Menotropins--
BADD_D01401Metformin0.000014%
BADD_D01513Nafarelin0.002142%
BADD_D01852Progesterone0.003388%
BADD_D02319Urofollitropin--
BADD_D02375Water--
BADD_D02460Ganirelix0.017343%
BADD_D02473Sodium chloride0.000845%
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