Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage For the treatment and prevention of osteoporosis in women and Paget's disease of bone in both men and women.
Marketing Status Prescription; Discontinued
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Angina unstable02.02.02.004; 24.04.04.0040.000303%Not Available
Angioedema10.01.05.009; 23.04.01.001--Not Available
Angle closure glaucoma06.03.01.0010.000202%Not Available
Anhedonia19.15.02.0070.003435%Not Available
Ankle fracture12.04.01.005; 15.08.03.0050.006668%
Anxiety19.06.02.0020.026875%
Aortic aneurysm24.02.03.0010.000505%Not Available
Aortic stenosis24.04.01.0010.001718%Not Available
Aortic valve incompetence02.07.03.0010.001718%Not Available
Aortic valve sclerosis02.07.03.0030.000404%Not Available
Aphasia17.02.03.001; 19.21.01.001--
Aphonia17.02.08.009; 19.19.01.002; 22.02.05.0240.000202%
Aphthous ulcer07.05.06.0020.000707%Not Available
Apnoea22.02.01.0010.000202%
Appendicitis07.19.01.001; 11.01.07.0010.000505%
Arrhythmia02.03.02.0010.002425%Not Available
Arrhythmia supraventricular02.03.03.0010.000303%Not Available
Arteriosclerosis24.04.02.0010.000580%Not Available
Arteriosclerosis coronary artery02.02.01.011; 24.04.04.0120.000580%Not Available
Arthralgia15.01.02.0010.029098%
Arthritis15.01.01.0010.017176%
Arthropathy15.01.01.0030.013337%Not Available
Aspartate aminotransferase increased13.03.01.006--
Aspiration22.02.07.0070.000105%
Aspiration pleural cavity13.19.03.0020.000303%Not Available
Asthenia08.01.01.0010.007376%Not Available
Asthma10.01.03.010; 22.03.01.0020.007982%Not Available
Ataxia08.01.02.004; 17.02.02.0010.000808%
Atelectasis22.01.02.0010.003738%
Atrial fibrillation02.03.03.0020.005658%
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