Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Hyperglycaemic hyperosmolar nonketotic syndrome
ADR ID BADD_A10062
ADR Hierarchy
14      Metabolism and nutrition disorders
14.07      Diabetic complications
14.07.04      Diabetic complications neurological
14.07.04.009      Hyperglycaemic hyperosmolar nonketotic syndrome
17      Nervous system disorders
17.02      Neurological disorders NEC
17.02.04      Disturbances in consciousness NEC
17.02.04.022      Hyperglycaemic hyperosmolar nonketotic syndrome
05      Endocrine disorders
05.07      Diabetic complications
05.07.04      Diabetic complications neurological
05.07.04.009      Hyperglycaemic hyperosmolar nonketotic syndrome
Description A serious complication of TYPE 2 DIABETES MELLITUS. It is characterized by extreme HYPERGLYCEMIA; DEHYDRATION; serum hyperosmolarity; and depressed consciousness leading to COMA in the absence of KETOSIS and ACIDOSIS. [MeSH]
MedDRA Code 10063554
MeSH ID D006944
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Diabetic hyperosmolar non-ketoacidosis | Hyperglycaemic hyperosmolar nonketotic syndrome | Hyperglycemic hyperosmolar nonketotic syndrome | Hyperosmolar hyperglycaemic state | Hyperosmolar hyperglycemic state | Hyperosmolar hyperglycemic syndrome | Hyperosmolar hyperglycaemic syndrome | Hyperosmolar non-ketotic hyperglycemia | Hyperosmolar non-ketotic hyperglycaemia | Hyperglycemic Hyperosmolar Nonketotic Coma | Nonketotic Hyperosmolar Coma | Coma, Nonketotic Hyperosmolar | Comas, Nonketotic Hyperosmolar | Hyperosmolar Coma, Nonketotic | Hyperosmolar Comas, Nonketotic | Nonketotic Hyperosmolar Comas | Nonketotic Hyperglycemic Coma | Coma, Nonketotic Hyperglycemic | Hyperglycemic Coma, Nonketotic | Hyperosmolar Nonketotic Coma | Coma, Hyperosmolar Nonketotic | Comas, Hyperosmolar Nonketotic | Hyperosmolar Nonketotic Comas | Nonketotic Coma, Hyperosmolar | Nonketotic Comas, Hyperosmolar | Coma, Hyperglycemic Hyperosmolar Nonketotic | Hyperosmolar Hyperglycemic Nonketotic Coma | Hyperosmolar Hyperglycemic State | Hyperglycemic State, Hyperosmolar | Hyperglycemic States, Hyperosmolar | Hyperosmolar Hyperglycemic States | Hyperosmolar Hyperglycemic Syndrome | Hyperglycemic Syndrome, Hyperosmolar | Hyperglycemic Syndromes, Hyperosmolar | Hyperosmolar Hyperglycemic Syndromes | Syndrome, Hyperosmolar Hyperglycemic | Syndromes, Hyperosmolar Hyperglycemic
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00014Abiraterone0.000501%
BADD_D00165Aripiprazole0.000079%
BADD_D00344Canagliflozin0.000180%
BADD_D00349Capecitabine0.000839%
BADD_D00578Dapagliflozin0.000658%
BADD_D00623Dexamethasone0.001090%
BADD_D00765Empagliflozin0.000410%
BADD_D00979Furosemide0.000028%
BADD_D01243Lamotrigine0.000083%
BADD_D01304Lithium cation0.000288%
BADD_D01401Metformin0.000024%
BADD_D01405Methadone0.000265%
BADD_D01599Olanzapine0.001368%
BADD_D01684Pasireotide0.000186%
BADD_D01831Prednisolone0.000087%
BADD_D01834Prednisone0.000063%
BADD_D01951Risperidone0.000546%
BADD_D01952Ritonavir0.001102%
BADD_D02105Tacrolimus0.002376%
BADD_D02415Ziprasidone0.000408%
BADD_D02500Alpelisib0.000839%
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