Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Drug-induced liver injury
ADR ID BADD_A06676
ADR Hierarchy
12      Injury, poisoning and procedural complications
12.03      Exposures, chemical injuries and poisoning
12.03.01      Poisoning and toxicity
12.03.01.044      Drug-induced liver injury
09      Hepatobiliary disorders
09.01      Hepatic and hepatobiliary disorders
09.01.07      Hepatocellular damage and hepatitis NEC
09.01.07.023      Drug-induced liver injury
Description A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment. | INFLAMMATION of the LIVER due to hepatocellular toxicity, caused by drug metabolites and chemicals from the environment. [MeSH]
MedDRA Code 10072268
MeSH ID D056486
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Drug-induced liver disease | Drug-induced hepatitis | Hepatitis allergic drug-induced | Hepatitis drug-induced | Hepatitis toxic drug-induced | Hy's law case | Drug-induced liver injury | DILI | Drug-induced hepatotoxicity | Herb-induced liver injury | Chemical and Drug Induced Liver Injury | Chemically-Induced Liver Toxicity | Chemically Induced Liver Toxicity | Chemically-Induced Liver Toxicities | Liver Toxicities, Chemically-Induced | Liver Toxicity, Chemically-Induced | Toxicities, Chemically-Induced Liver | Toxicity, Chemically-Induced Liver | Drug-Induced Acute Liver Injury | Drug Induced Acute Liver Injury | Liver Injury, Drug-Induced, Acute | Acute Liver Injury, Drug-Induced | Acute Liver Injury, Drug Induced | Hepatitis, Toxic | Toxic Hepatitis | Hepatitides, Toxic | Toxic Hepatitides | Drug-Induced Liver Disease | Disease, Drug-Induced Liver | Diseases, Drug-Induced Liver | Drug Induced Liver Disease | Drug-Induced Liver Diseases | Liver Disease, Drug-Induced | Liver Diseases, Drug-Induced | Drug-Induced Liver Injury | Drug Induced Liver Injury | Drug-Induced Liver Injuries | Injuries, Drug-Induced Liver | Injury, Drug-Induced Liver | Liver Injuries, Drug-Induced | Liver Injury, Drug-Induced | Liver Injury, Drug Induced | Hepatitis, Drug-Induced | Drug-Induced Hepatitides | Drug-Induced Hepatitis | Hepatitides, Drug-Induced | Hepatitis, Drug Induced
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01557Nevirapine0.010608%
BADD_D01566Nifedipine0.000187%
BADD_D01576Nitrofurantoin--
BADD_D01599Olanzapine0.001789%
BADD_D01601Olaparib0.000616%
BADD_D01602Olmesartan0.000577%
BADD_D01624Orlistat0.008483%
BADD_D01629Osimertinib0.001119%
BADD_D01631Oxacillin0.000267%
BADD_D01633Oxaliplatin0.001668%
BADD_D01635Oxaprozin0.003638%
BADD_D01637Oxcarbazepine0.000596%
BADD_D01668Pantoprazole0.000139%
BADD_D01679Paroxetine--
BADD_D01687Pazopanib0.000783%
BADD_D01701Pemetrexed0.000112%
BADD_D01733Perampanel0.000125%
BADD_D01752Phenobarbital0.000813%
BADD_D01756Phentermine0.000327%
BADD_D01765Phenytoin0.002677%
BADD_D01777Pioglitazone--
BADD_D01784Piroxicam0.001595%
BADD_D01804Posaconazole0.018913%
BADD_D01817Pramipexole0.000478%
BADD_D01822Prasugrel0.000384%
BADD_D01824Pravastatin--
BADD_D01834Prednisone0.000076%
BADD_D01852Progesterone--
BADD_D01854Promethazine0.000077%
BADD_D01856Propafenone0.001045%
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