ADReCS

Pharmaceutical Information

Drug Name	Propafenone
Drug ID	BADD_D01856
Description	An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated.
Indications and Usage	Used to prolong the time to recurrence of paroxysmal atrial fibrillation/flutter (PAF) associated with disabling symptoms in patients without structural heart disease. Also used for the treatment of life-threatening documented ventricular arrhythmias, such as sustained ventricular tachycardia.
Marketing Status	approved
ATC Code	C01BC03
DrugBank ID	DB01182
KEGG ID	D08435
MeSH ID	D011405
PubChem ID	4932
TTD Drug ID	D0J2KV
NDC Product Code	51407-478; 24979-086; 69680-130; 69680-131; 71205-942; 12598-6285; 71205-941; 24979-087; 24979-085; 51407-477; 71205-940; 69680-132; 51407-479
UNII	68IQX3T69U
Synonyms	Propafenone \| Propafenone Hydrochloride, (R)-Isomer \| Rytmo-Puren \| Rytmogenat \| SA-79 \| SA 79 \| SA79 \| Propafenone, (+-)-Isomer \| Propafenone, (R)-Isomer \| Propafenone, (S)-Isomer \| Propamerck \| Apo-Propafenone \| Baxarytmon \| Cuxafenon \| Fenoprain \| Jutanorm \| Nistaken \| Prolecofen \| Propafenon AL \| Propafenon Hexal \| Propafenone Hydrochloride \| Hydrochloride, Propafenone \| Propafenone Hydrochloride, (S)-Isomer \| Rythmol \| Propafenon Minden \| Norfenon \| Pintoform \| Rytmonorm \| Arythmol

Chemical Information

Molecular Formula	C21H27NO3
CAS Registry Number	54063-53-5
SMILES	CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Abdominal distension	07.01.04.001	-	-
Abdominal pain	07.01.05.002	0.001045%
Abnormal dreams	17.15.02.001; 19.02.03.001	-	-	-
Agitation	17.02.05.012; 19.06.02.001	0.000627%
Agranulocytosis	01.02.03.001	-	-	-
Alanine aminotransferase increased	13.03.04.005	-	-
Alopecia	23.02.02.001	-	-
Altered state of consciousness	17.02.04.001; 19.07.01.003	0.000836%		-
Amnesia	17.03.02.001; 19.20.01.001	-	-
Anaemia	01.03.02.001	0.000627%
Angina pectoris	02.02.02.002; 24.04.04.002	0.000627%
Angina unstable	02.02.02.004; 24.04.04.004	-	-	-
Anxiety	19.06.02.002	0.001045%
Apnoea	22.02.01.001	-	-
Arrhythmia	02.03.02.001	0.003762%		-
Arrhythmia supraventricular	02.03.03.001	-	-	-
Arthritis	15.01.01.001	-	-
Arthropathy	15.01.01.003	-	-	-
Aspartate aminotransferase increased	13.03.04.011	-	-
Asthenia	08.01.01.001	0.001672%		-
Ataxia	08.01.02.004; 17.02.02.001	-	-
Atelectasis	22.01.02.001	-	-
Atrial fibrillation	02.03.03.002	0.004891%
Atrial flutter	02.03.03.003	0.000627%
Atrioventricular block	02.03.01.002	0.000418%		-
Atrioventricular block first degree	02.03.01.004	0.001463%
Atrioventricular block second degree	02.03.01.005	0.000920%
Bleeding time prolonged	13.01.02.002	-	-	-
Blister	12.01.06.002; 23.03.01.001	-	-	-
Blood bilirubin increased	13.03.04.018	-	-

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