Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Propafenone
Drug ID BADD_D01856
Description An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated.
Indications and Usage Used to prolong the time to recurrence of paroxysmal atrial fibrillation/flutter (PAF) associated with disabling symptoms in patients without structural heart disease. Also used for the treatment of life-threatening documented ventricular arrhythmias, such as sustained ventricular tachycardia.
Marketing Status Prescription; Discontinued
ATC Code C01BC03
DrugBank ID DB01182
KEGG ID D08435
MeSH ID D011405
PubChem ID 4932
TTD Drug ID D0J2KV
NDC Product Code 51407-477; 51407-479; 24979-087; 71205-940; 12598-6285; 51407-478; 24979-085; 69680-130; 71205-941; 69680-132; 69680-131; 71205-942; 24979-086
Synonyms Propafenone | Propafenone Hydrochloride, (R)-Isomer | Rytmo-Puren | Rytmogenat | SA-79 | SA 79 | SA79 | Propafenone, (+-)-Isomer | Propafenone, (R)-Isomer | Propafenone, (S)-Isomer | Propamerck | Apo-Propafenone | Baxarytmon | Cuxafenon | Fenoprain | Jutanorm | Nistaken | Prolecofen | Propafenon AL | Propafenon Hexal | Propafenone Hydrochloride | Hydrochloride, Propafenone | Propafenone Hydrochloride, (S)-Isomer | Rythmol | Propafenon Minden | Norfenon | Pintoform | Rytmonorm | Arythmol
Chemical Information
Molecular Formula C21H27NO3
CAS Registry Number 54063-53-5
SMILES CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.0020.004790%
Abdominal pain upper07.01.05.0030.001916%
Abnormal dreams17.15.02.001; 19.02.03.001--Not Available
Agitation17.02.05.012; 19.06.02.0010.002874%
Agranulocytosis01.02.03.001--Not Available
Alanine aminotransferase increased13.03.01.0030.001916%
Alopecia23.02.02.001--
Altered state of consciousness17.02.04.001; 19.07.01.0030.001916%Not Available
Amnesia17.03.02.001; 19.20.01.001--
Anaemia01.03.02.0010.002874%
Angina pectoris02.02.02.002; 24.04.04.0020.002874%
Angina unstable02.02.02.004; 24.04.04.004--Not Available
Anxiety19.06.02.0020.004790%
Apnoea22.02.01.001--
Arrhythmia02.03.02.0010.002999%Not Available
Arrhythmia supraventricular02.03.03.001--Not Available
Arthritis15.01.01.001--
Arthropathy15.01.01.003--Not Available
Aspartate aminotransferase increased13.03.01.0060.001916%
Asthenia08.01.01.0010.005747%Not Available
Ataxia08.01.02.004; 17.02.02.001--
Atelectasis22.01.02.001--
Atrial fibrillation02.03.03.0020.014369%
Atrial flutter02.03.03.0030.001916%
Atrioventricular block02.03.01.002--Not Available
Atrioventricular block first degree02.03.01.0040.004790%
Atrioventricular block second degree02.03.01.0050.001916%
Bleeding time prolonged13.01.02.002--Not Available
Blister12.01.06.002; 23.03.01.001--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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