Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Intervertebral disc protrusion
ADR ID BADD_A04928
ADR Hierarchy
15      Musculoskeletal and connective tissue disorders
15.10      Musculoskeletal and connective tissue deformities (incl intervertebral disc disorders)
15.10.01      Intervertebral disc disorders NEC
15.10.01.004      Intervertebral disc protrusion
Description An INTERVERTEBRAL DISC in which the NUCLEUS PULPOSUS has protruded through surrounding ANNULUS FIBROSUS. This occurs most frequently in the lower lumbar region. [MeSH]
MedDRA Code 10050296
MeSH ID D007405
ADR Severity Grade (FAERS) Not Available
ADR Severity Grade (CTCAE) Not Available
Synonym
Intervertebral disc prolapse | Prolapsed cervical disc | Prolapsed disc NOS | Prolapsed lumbar disc | Schmorl's nodes | Schmorl's nodes of lumbar region | Schmorl's nodes of other spinal region | Schmorl's nodes of thoracic region | Schmorl's nodes of unspecified region | Slipped cervical disc | Slipped disc | Slipped lumbar disc | Herniated disk NOS | Herniated nucleus pulposus | Intervertebral disc herniation | Intervertebral disc protrusion | Herniated disc | Ruptured intervertebral disc | Lumbar disc herniation | Cervical disc herniation | Thoracic disc herniation | Intervertebral disc bulging | Vertebral hernia | Intervertebral disc sequestration | Intervertebral disc extrusion | Fragmented intervertebral disc | Schmorl's hernia | Lumbosacral disc herniation | Intervertebral Disc Displacement | Disc Displacement, Intervertebral | Disc Displacements, Intervertebral | Intervertebral Disc Displacements | Disk, Herniated | Disks, Herniated | Herniated Disks | Slipped Disk | Disk, Slipped | Disks, Slipped | Slipped Disks | Disk Prolapse | Disk Prolapses | Prolapse, Disk | Prolapses, Disk | Prolapsed Disc | Disc, Prolapsed | Discs, Prolapsed | Prolapsed Discs | Herniated Disc | Discs, Herniated | Herniated Discs | Disc, Herniated | Herniated Disk | Slipped Disc | Disc, Slipped | Discs, Slipped | Slipped Discs | Intervertebral Disk Displacement | Disk Displacement, Intervertebral | Disk Displacements, Intervertebral | Intervertebral Disk Displacements | Prolapsed Disk | Disk, Prolapsed | Disks, Prolapsed | Prolapsed Disks
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01136Imatinib0.000750%
BADD_D01213Isotretinoin0.001081%
BADD_D01242Lamivudine0.001012%
BADD_D01252Leflunomide0.001285%
BADD_D01253Lenalidomide0.013092%
BADD_D01257Letrozole0.000263%
BADD_D01260Leuprolide acetate0.002151%
BADD_D01275Levofloxacin0.000042%
BADD_D01285Levothyroxine0.000005%
BADD_D01322Losartan0.000015%
BADD_D01336Macitentan0.000650%
BADD_D01401Metformin0.000019%
BADD_D01418Methotrexate--
BADD_D01476Mirtazapine0.000080%
BADD_D01498Morphine--
BADD_D01533Naproxen--
BADD_D01564Nicotine0.000940%
BADD_D01567Nilotinib0.000940%
BADD_D01783Pirfenidone0.000362%
BADD_D01817Pramipexole--
BADD_D01818Pramipexole dihydrochloride--
BADD_D01831Prednisolone0.000070%
BADD_D01834Prednisone--
BADD_D01835Pregabalin0.001437%
BADD_D01922Regorafenib0.000112%
BADD_D01933Ribavirin0.013845%
BADD_D01966Ropinirole--
BADD_D01971Rosuvastatin0.000026%
BADD_D02010Sertraline0.000038%
BADD_D02018Sildenafil0.000107%
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ADReCS-Target
ADR Term Drug Name Target