| Drug Name |
Estradiol |
| Drug ID |
BADD_D00821 |
| Description |
Estradiol is a naturally occurring hormone circulating endogenously in females. It is commercially available in several hormone therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and hot flashes. Some available forms of estradiol include oral tablets, injections, vaginal rings, transdermal patches, sprays, gels, and creams.[L11485,L11488,L11491, L11494,L11497,L11500,L11503]
When used for oral or IM administration, estradiol is commonly synthesized as a pro-drug ester (such as [DB13952], [DB13953], [DB13954], [DB13955], and [DB13956]). Because it has a low oral bioavailability on its own, estradiol is commonly formulated with an ester side-chain. [DB00977] (EE) is a synthetic form of estradiol commonly used as the estrogenic component of most combination oral contraceptive pills (OCPs). Ethinyl estradiol is different from estradiol due to its higher biovailability and increased resistance to metabolism, rendering it more suitable for oral administration. |
| Indications and Usage |
Estradiol is indicated for the treatment of moderate to severe vasomotor symptoms and vulvar and vaginal atrophy due to menopause, for the treatment of hypoestrogenism due to hypogonadism, castration, or primary ovarian failure, and for the prevention of post-menopausal osteoarthritis. It is also used for the treatment of breast cancer (for palliation only) in appropriately selected women and men with metastatic disease, and for the treatment of advanced androgen-dependent carcinoma of the prostate (for palliation only). |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
G03CA03 |
| DrugBank ID |
DB00783
|
| KEGG ID |
D00105
|
| MeSH ID |
D004958
|
| PubChem ID |
5757
|
| TTD Drug ID |
D08QMX
|
| NDC Product Code |
76420-022; 0430-0721; 63629-4788; 43063-706; 0781-7119; 0169-5176; 70518-0920; 70934-541; 54348-702; 43063-717; 72189-183; 68788-7961; 38779-2261; 46144-400; 69238-1294; 0781-7104; 68025-066; 0378-4640; 70518-2595; 61919-195; 72189-198; 71335-0797; 50090-3645; 52483-9104; 0430-3754; 0023-5886; 0093-3223; 63083-1557; 42291-962; 60429-833; 0395-8065; 11014-0320; 11014-0321; 51862-334; 69238-1296; 0093-3541; 0574-2067; 65162-126; 68025-067; 65162-992; 0013-2150; 61919-278; 63629-8803; 42806-089; 0378-4641; 68788-7892; 70518-2829; 70934-215; 50261-110; 0378-3349; 68788-8063; 68968-6675; 69238-1295; 0378-4643; 49452-2801; 0078-0344; 0430-0722; 63539-021; 68788-7332; 68025-065; 12860-0218; 50090-5494; 0802-8065; 60429-834; 63629-8804; 0378-4620; 70934-506; 0781-7138; 68968-6637; 76420-680; 51862-332; 69238-1447; 68968-3437; 68071-2487; 71335-1973; 65162-993; 76420-023; 70518-2368; 0078-0343; 50419-453; 0378-4621; 0430-0720; 68025-083; 65162-995; 52483-9254; 0378-8770; 71335-1488; 52483-9504; 70518-2369; 0555-0887; 0078-0365; 68968-3410; 60870-0218; 24658-702; 0378-3361; 68462-711; 71335-0430; 24658-703; 0555-0899; 0378-3352; 51862-333; 69238-1629; 68968-3475; 0378-3360; 71335-0201; 48087-0159; 70934-927; 0781-7122; 66993-002; 71335-0226; 65162-989; 68968-6650; 54348-701; 17139-617; 68981-012; 65162-150; 65162-226; 60429-835; 47781-104; 0078-0345; 44132-009; 50419-455; 24658-704; 0378-4644; 0781-7133; 51552-0384; 50419-456; 69238-1631; 50090-1704; 50419-459; 76420-681; 53746-226; 50419-451; 0023-5887; 68025-086; 68071-2429; 0555-0886; 69238-1630; 63629-8802; 0781-7134; 65162-228; 76420-021; 68071-3394; 45541-1124; 70934-393; 50419-454; 0023-5888; 69238-1632; 68968-3450; 0378-4623; 50090-3327; 65162-997; 0781-7156; 68788-7102; 42291-426; 0378-3350; 42806-087; 0378-4642; 71335-0445; 69238-1293; 0115-1518; 0037-4801; 63629-8654; 0023-5885; 69238-1633; 0781-7136; 50261-104; 71335-1719; 70934-798; 63629-8713; 65162-148; 68968-6625; 0078-0346; 50419-452; 42806-088; 68968-6610; 38779-0869; 45802-097; 63187-741; 68981-013; 0781-7129; 0378-3351; 0378-4622; 76420-048; 50090-2321; 68968-3425; 65162-149; 70934-786; 0378-4619; 0781-7167; 70518-0834; 44132-001; 0781-7144 |
| Synonyms |
Estradiol | Estradiol-17 beta | Estradiol 17 beta | Estradiol Anhydrous | Oestradiol | Estradiol-17beta | Estradiol 17beta | 17 beta-Estradiol | 17 beta Estradiol | 17 beta-Oestradiol | 17 beta Oestradiol | Progynova | Estradiol, (9 beta,17 alpha)-Isomer | Estradiol, (9 beta,17 beta)-Isomer | Estradiol, Monosodium Salt | Estradiol, Sodium Salt | Vivelle | Aerodiol | Estrace | Estraderm TTS | Estradiol Hemihydrate | Estradiol Hemihydrate, (17 alpha)-Isomer | Estradiol Monohydrate | Estradiol, (+-)-Isomer | Estradiol, (-)-Isomer | Estradiol, (16 alpha,17 alpha)-Isomer | Estradiol, (16 alpha,17 beta)-Isomer | Estradiol, (8 alpha,17 beta)-(+-)-Isomer | Estradiol, (8 alpha,17 beta)-Isomer | Estradiol Valerate | Estradiol Valeriante | Progynon-Depot | Progynon Depot | Delestrogen | Estradiol-17 alpha | Estradiol 17 alpha | Estradiol, (17-alpha)-Isomer | Ovocyclin |
