Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Folate deficiency
ADR ID BADD_A01678
ADR Hierarchy
14      Metabolism and nutrition disorders
14.12      Vitamin related disorders
14.12.02      Water soluble vitamin deficiencies
14.12.02.006      Folate deficiency
Description A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed) [MeSH]
MedDRA Code 10016880
MeSH ID D005494
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Folate deficiency | Folic acid deficiency | Folic Acid Deficiency | Deficiency, Folic Acid | Acid Deficiencies, Folic | Acid Deficiency, Folic | Deficiencies, Folic Acid | Folic Acid Deficiencies
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00165Aripiprazole0.000079%
BADD_D00356Carbamazepine0.000279%
BADD_D00511Clozapine0.001223%
BADD_D00520Colestilan chloride--
BADD_D00696Divalproex sodium--
BADD_D01110Hydroxyurea--
BADD_D01401Metformin0.000046%
BADD_D01418Methotrexate0.000284%
BADD_D01476Mirtazapine0.000160%
BADD_D01601Olaparib0.000336%
BADD_D01637Oxcarbazepine--
BADD_D01645Oxycodone0.000021%
BADD_D01752Phenobarbital--
BADD_D02010Sertraline0.000019%
BADD_D02093Sulfasalazine--
BADD_D02329Valproic acid--
BADD_D02464Fingolimod0.000482%
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