Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Constipation
ADR ID BADD_A01059
ADR Hierarchy
07      Gastrointestinal disorders
07.02      Gastrointestinal motility and defaecation conditions
07.02.02      Gastrointestinal atonic and hypomotility disorders NEC
07.02.02.001      Constipation
Description A disorder characterized by irregular and infrequent or difficult evacuation of the bowels. [CTCAE] Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections. | Difficult defecation. | Symptom characterized by the passage of stool once a week or less. [MeSH]
MedDRA Code 10010774
MeSH ID D003248
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Constipation | Constipation (excl faecal impaction) | Iatrogenic constipation | Obstipation | Constipation aggravated | Constipation (excl fecal impaction) | Stools absent | Constipation chronic | Opioid induced constipation | Slow transit constipation | Chronic idiopathic constipation | Absent bowel movement | Habitual constipation | Dyschezia | Colonic Inertia
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01376Melphalan0.000448%
BADD_D01378Memantine0.000786%
BADD_D01379Memantine hydrochloride--
BADD_D01381Mepact--
BADD_D01382Mepenzolate--
BADD_D01383Mepenzolate bromide--
BADD_D01384Meperidine--
BADD_D01385Meperidine hydrochloride--
BADD_D01391Mercaptoethanesulfonic acid--
BADD_D01392Mercaptopurine--
BADD_D01393Meropenem--
BADD_D01394Merrem i.v.--
BADD_D01395Mersyndol--
BADD_D01397Mesalamine--
BADD_D01398Mesna--
BADD_D01401Metformin--
BADD_D01402Metformin hydrochloride--
BADD_D01405Methadone--
BADD_D01406Methadone hydrochloride--
BADD_D01407Methamphetamine--
BADD_D01408Methamphetamine hydrochloride--
BADD_D01414Methimazole--
BADD_D01415Methocarbamol0.000312%
BADD_D01421Methoxy polyethylene glycol-epoetin beta--
BADD_D01422Methsuximide--
BADD_D01423Methyclothiazide--
BADD_D01425Methyldopa--
BADD_D01426Methyldopate hydrochloride--
BADD_D01431Methylphenidate--
BADD_D01437Methylscopolamine bromide--
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