Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Methyclothiazide
Drug ID BADD_D01423
Description A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p825)
Indications and Usage For use in the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension. Also used as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy.
Marketing Status withdrawn
ATC Code C03AA08
DrugBank ID DB00232
KEGG ID D00656
MeSH ID D008736
PubChem ID 4121
TTD Drug ID D03GVC
NDC Product Code 12828-0023
UNII L3H46UAC61
Synonyms Methyclothiazide
Chemical Information
Molecular Formula C9H11Cl2N3O4S2
CAS Registry Number 135-07-9
SMILES CN1C(NC2=CC(=C(C=C2S1(=O)=O)S(=O)(=O)N)Cl)CCl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation17.02.05.012; 19.06.02.001--
Agranulocytosis01.02.03.001---
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Anaphylactic shock10.01.07.002; 24.06.02.004---
Aplastic anaemia01.03.03.002---
Asthenia08.01.01.001---
Blood uric acid increased13.02.04.001---
Body temperature increased13.15.01.001---
Constipation07.02.02.001--
Cutaneous vasculitis10.02.02.003; 23.06.02.001; 24.12.04.008---
Dermatitis23.03.04.002---
Diarrhoea07.02.01.001--
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Electrolyte imbalance14.05.01.002---
Erythema multiforme10.01.03.015; 23.03.01.003--
Glycosuria20.02.01.005--
Haemolytic anaemia01.06.03.002---
Headache17.14.01.001--
Hypercalcaemia05.04.01.002; 14.04.01.003--
Hyperglycaemia05.06.02.002; 14.06.02.002--
Hypersensitivity10.01.03.003--
Hyperuricaemia14.09.01.003--
Jaundice01.06.04.004; 09.01.01.004; 23.03.03.030---
Jaundice cholestatic09.01.01.005---
Leukopenia01.02.02.001---
Muscle spasms15.05.03.004--
Nausea07.01.07.001--
Orthostatic hypotension17.05.01.020; 24.06.03.004---
Pancreatitis07.18.01.001--
Paraesthesia17.02.06.005; 23.03.03.094--
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