Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Coma hepatic
ADR ID BADD_A00986
ADR Hierarchy
17      Nervous system disorders
17.02      Neurological disorders NEC
17.02.09      Coma states
17.02.09.002      Coma hepatic
09      Hepatobiliary disorders
09.01      Hepatic and hepatobiliary disorders
09.01.03      Hepatic failure and associated disorders
09.01.03.005      Coma hepatic
Description A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5) [MeSH]
MedDRA Code 10010075
MeSH ID D006501
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Coma hepatic | Hepatic coma | Hepatic Encephalopathy | Encephalopathies, Hepatic | Hepatic Encephalopathies | Encephalopathy, Hepatic | Portal-Systemic Encephalopathy | Portal Systemic Encephalopathy | Encephalopathy, Portal-Systemic | Encephalopathies, Portal-Systemic | Encephalopathy, Portal Systemic | Portal-Systemic Encephalopathies | Encephalopathy, Portosystemic | Hepatocerebral Encephalopathy | Portosystemic Encephalopathy | Encephalopathies, Portosystemic | Portosystemic Encephalopathies | Encephalopathy, Hepatocerebral | Encephalopathies, Hepatocerebral | Hepatocerebral Encephalopathies | Hepatic Coma | Coma, Hepatic | Comas, Hepatic | Hepatic Comas | Hepatic Stupor | Hepatic Stupors | Stupor, Hepatic | Stupors, Hepatic | Fulminant Hepatic Failure with Cerebral Edema
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00014Abiraterone0.000334%
BADD_D00194Azacitidine--
BADD_D00349Capecitabine--
BADD_D00555Cyproterone acetate--
BADD_D00594Deferasirox0.001239%
BADD_D00631Dexmethylphenidate hydrochloride--
BADD_D00699Docetaxel--
BADD_D00765Empagliflozin0.000091%
BADD_D00774Entecavir0.003269%
BADD_D00934Fluoxymesterone--
BADD_D01040Granisetron--
BADD_D01057Halothane--
BADD_D01204Isoniazid0.008339%
BADD_D01254Lenvatinib0.000112%
BADD_D01431Methylphenidate--
BADD_D01432Methylphenidate hydrochloride--
BADD_D01765Phenytoin0.000191%
BADD_D01835Pregabalin0.000052%
BADD_D01922Regorafenib0.000392%
BADD_D01933Ribavirin0.005934%
BADD_D01952Ritonavir--
BADD_D01954Rivaroxaban0.000095%
BADD_D02058Sorafenib0.000336%
BADD_D02217Tigecycline0.000049%
BADD_D02246Tolvaptan0.000058%
BADD_D02369Voriconazole--
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