Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Addison's disease
ADR ID BADD_A00090
ADR Hierarchy
10      Immune system disorders
10.04      Autoimmune disorders
10.04.08      Endocrine autoimmune disorders
10.04.08.008      Addison's disease
05      Endocrine disorders
05.01      Adrenal gland disorders
05.01.02      Adrenal cortical hypofunctions
05.01.02.006      Addison's disease
14      Metabolism and nutrition disorders
14.11      Metabolism disorders NEC
14.11.01      Metabolic disorders NEC
14.11.01.025      Addison's disease
Description An adrenal disease characterized by the progressive destruction of the ADRENAL CORTEX, resulting in insufficient production of ALDOSTERONE and HYDROCORTISONE. Clinical symptoms include ANOREXIA; NAUSEA; WEIGHT LOSS; MUSCLE WEAKNESS; and HYPERPIGMENTATION of the SKIN due to increase in circulating levels of ACTH precursor hormone which stimulates MELANOCYTES. [MeSH]
MedDRA Code 10001130
MeSH ID D000224
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Addison's disease | Adrenocortical insufficiency chronic | Disease Addison's | Autoimmune adrenal insufficiency | Autoimmune adrenalitis | Addison Disease | Disease, Addison | Primary Adrenal Insufficiency | Adrenal Insufficiency, Primary | Primary Hypoadrenalism | Hypoadrenalism, Primary | Hypoadrenalisms, Primary | Addison's Disease | Addisons Disease | Primary Adrenocortical Insufficiency | Adrenocortical Insufficiencies, Primary | Adrenocortical Insufficiency, Primary | Insufficiencies, Primary Adrenocortical | Insufficiency, Primary Adrenocortical | Primary Adrenocortical Insufficiencies
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00014Abiraterone0.000667%
BADD_D00318Busulfan--
BADD_D01096Hydromorphone--
BADD_D01433Methylprednisolone0.000032%
BADD_D01498Morphine--
BADD_D01645Oxycodone--
BADD_D01684Pasireotide0.000186%
BADD_D01685Pasireotide diaspartate--
BADD_D01831Prednisolone0.000052%
BADD_D01834Prednisone0.000009%
BADD_D02010Sertraline0.000032%
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