Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Acute hepatic failure
ADR ID BADD_A00075
ADR Hierarchy
09      Hepatobiliary disorders
09.01      Hepatic and hepatobiliary disorders
09.01.03      Hepatic failure and associated disorders
09.01.03.001      Acute hepatic failure
Description A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C. [MeSH]
MedDRA Code 10000804
MeSH ID D017114
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Acute hepatic failure | Fulminant hepatic failure | Acute liver failure | Liver Failure, Acute | Failure, Acute Liver | Fulminating Hepatic Failure | Fulminating Hepatic Failures | Hepatic Failure, Fulminating | Hepatic Failures, Fulminating | Liver Failure, Fulminant | Fulminant Liver Failure | Fulminant Liver Failures | Liver Failures, Fulminant | Hepatic Failure, Acute | Acute Hepatic Failure | Failure, Acute Hepatic | Hepatic Failure, Fulminant | Fulminant Hepatic Failure | Fulminant Hepatic Failures | Hepatic Failures, Fulminant | Acute Liver Failure | Fulminating Liver Failure | Fulminating Liver Failures | Liver Failure, Fulminating | Liver Failures, Fulminating
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00979Furosemide0.000021%
BADD_D01009Gemcitabine0.000224%
BADD_D01035Golimumab--
BADD_D01054Haloperidol--
BADD_D01081Hydralazine0.000477%
BADD_D01103Hydroxychloroquine0.001859%
BADD_D01104Hydroxychloroquine sulfate--
BADD_D01110Hydroxyurea0.000112%
BADD_D01120Ibuprofen0.000009%
BADD_D01136Imatinib0.000750%
BADD_D01157Infliximab--
BADD_D01194Irbesartan0.000441%
BADD_D01204Isoniazid0.045032%
BADD_D01217Itraconazole0.005345%
BADD_D01222Ixabepilone--
BADD_D01238Lacosamide0.002925%
BADD_D01243Lamotrigine0.000386%
BADD_D01252Leflunomide0.000857%
BADD_D01253Lenalidomide--
BADD_D01254Lenvatinib0.000224%
BADD_D01258Leucovorin0.001239%
BADD_D01265Levetiracetam0.000692%
BADD_D01275Levofloxacin0.000105%
BADD_D01295Linezolid0.006586%
BADD_D01300Lisinopril0.000030%
BADD_D01318Lorazepam0.000031%
BADD_D01395Mersyndol--
BADD_D01401Metformin0.000062%
BADD_D01414Methimazole0.000607%
BADD_D01425Methyldopa0.001027%
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ADReCS-Target
ADR Term Drug Name Target