Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Rivastigmine
Drug ID BADD_D01955
Description Rivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer's type. Rivastigmine is a cholinesterase inhibitor that inhibits both butyrylcholinesterase and acetylcholinesterase.
Indications and Usage For the treatment of mild to moderate dementia associated with Parkinson's disease or of the Alzheimer's type.
Marketing Status approved; investigational
ATC Code N06DA03
DrugBank ID DB00989
KEGG ID D03822
MeSH ID D000068836
PubChem ID 77991
TTD Drug ID D0WY5Q
NDC Product Code 16714-117; 70710-1198; 72855-101; 0781-7304; 65372-1153; 82245-0107; 51956-0001; 51956-0002; 51991-898; 65162-826; 72855-102; 49706-1825; 0078-0503; 63629-2065; 65162-749; 65162-825; 0378-9072; 0781-7309; 12651-118; 64552-4021; 65015-819; 0078-0501; 63629-8846; 0378-9071; 70710-1196; 16714-115; 63629-2066; 50379-0014; 65862-982; 72855-100; 51956-0003; 51991-897; 51991-899; 0781-7313; 63629-2064; 0378-9070; 0078-0502; 16714-116; 63629-8807; 70710-1197
UNII PKI06M3IW0
Synonyms Rivastigmine | (S)-N-Ethyl-3-((1-dimethyl-amino)ethyl)-N-methylphenylcarbamate | RivastigmineTartrate | Rivastigmine Hydrogen Tartrate | Hydrogen Tartrate, Rivastigmine | Tartrate, Rivastigmine Hydrogen | Exelon | ENA 713 | 713, ENA | SDZ ENA 713 | 713, SDZ ENA | ENA 713, SDZ | ENA-713 | ENA713
Chemical Information
Molecular Formula C14H22N2O2
CAS Registry Number 123441-03-2
SMILES CCN(C)C(=O)OC1=CC=CC(=C1)C(C)N(C)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Atrioventricular block complete02.03.01.0030.001626%
Atrioventricular block second degree02.03.01.0050.001084%
Bladder cancer16.08.01.001; 20.03.04.001---
Blister12.01.06.002; 23.03.01.0010.001192%-
Blood pressure fluctuation24.06.01.0020.000542%-
Bradycardia02.03.02.0020.006775%-
Bradykinesia17.01.02.0040.001355%-
Cardiac arrest02.03.04.0010.004336%
Cardiac failure02.05.01.0010.003523%
Cardiac failure congestive02.05.01.002---
Cardio-respiratory arrest02.03.04.002; 22.02.06.0070.000813%-
Cardiomegaly02.04.02.0010.000542%-
Catatonia19.11.01.0010.001626%-
Cerebral atrophy17.11.01.0010.000542%-
Cerebral haemorrhage17.08.01.003; 24.07.04.0010.000813%-
Cerebral infarction17.08.01.004; 24.04.06.0020.000542%-
Cerebrovascular accident17.08.01.007; 24.03.05.0010.007588%
Cerebrovascular disorder17.08.02.002; 24.03.05.002---
Chills08.01.09.001; 15.05.03.0160.002005%
Choking22.12.03.003---
Cholecystitis09.03.01.001--
Cholecystitis acute09.03.01.0030.000542%-
Cholelithiasis09.03.01.0020.000542%-
Cholinergic syndrome17.05.01.0020.002439%-
Chronic obstructive pulmonary disease22.03.01.0070.001084%-
Circulatory collapse24.06.02.0010.001084%-
Cogwheel rigidity15.05.04.006; 17.01.05.001---
Cold sweat08.01.03.024; 23.02.03.0020.000813%-
Colitis ischaemic07.08.01.004; 24.04.08.0120.000542%-
Colon cancer07.21.01.001; 16.13.01.0010.001084%-
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ADReCS-Target
Drug Name ADR Term Target
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