Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Proparacaine
Drug ID BADD_D01862
Description Proparacaine is a topical anesthetic drug of the amino ester group. It is found in ophthalmic solutions at a concentration of 0.5% as the hydrochloride salt.
Indications and Usage Used as a local (ophthalmic) anesthetic.
Marketing Status approved; vet_approved
ATC Code S01HA04
DrugBank ID DB00807
KEGG ID D08448
MeSH ID C005717
PubChem ID 4935
TTD Drug ID D0Q7ZG
NDC Product Code Not Available
UNII B4OB0JHI1X
Synonyms proxymetacaine | benzoic acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl ester | proparacaine | proxymethacaine | 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate | Alcaine | Chibro-Kerakain | Kainair | Kéracaine | proxymetacaine hydrochloride | proparacaine HCl | proxymetacaine monohydrochloride | benzoic acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl ester, monohydrochloride*benzoic acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl ester, monohydrochloride | proparacaine hydrochloride | 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate monohydrochloride | Ocu-Caine | Ophthaine | Ophthetic | Parcaine | Proparakain-POS | AK-Taine | Minims Proxymetacaine Hydrochloride
Chemical Information
Molecular Formula C16H26N2O3
CAS Registry Number 499-67-2
SMILES CCCOC1=C(C=C(C=C1)C(=O)OCCN(CC)CC)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blepharospasm06.05.01.001; 17.17.02.0010.000161%-
Chest discomfort02.02.02.009; 08.01.08.019; 22.12.02.0020.000107%-
Corneal epithelium defect06.06.03.0120.000484%-
Corneal erosion06.06.03.0030.000107%-
Corneal infiltrates06.08.01.0020.000645%-
Corneal oedema06.04.02.0010.000967%-
Corneal opacity06.06.03.0050.000430%-
Corneal perforation06.06.03.006; 12.01.04.0030.000107%-
Dermatitis contact10.01.01.003; 12.03.01.040; 23.03.04.004---
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.0070.000161%
Drug abuse19.07.06.0100.001128%-
Dyspnoea02.11.05.003; 22.02.01.0040.000107%
Eye irritation06.04.05.0030.000419%-
Eye pain06.08.03.0020.000430%
Eyelid oedema06.04.04.004; 10.01.05.001; 23.04.01.0030.000161%-
Haemoglobin13.01.05.018---
Iritis06.04.03.002; 10.02.01.022---
Keratitis06.04.02.0020.000107%
Keratopathy06.06.03.0070.001182%-
Lacrimation increased06.08.02.0040.000107%
Liver disorder09.01.08.001---
Loss of consciousness17.02.04.0040.000161%-
Mydriasis06.05.03.004; 17.02.11.003---
Necrosis08.03.03.001; 24.04.02.006---
Ocular hyperaemia06.04.05.0040.000473%-
Pain08.01.08.004--
Photophobia06.01.01.004; 17.17.02.0060.000376%
Retinal disorder06.08.03.0050.000322%-
Syncope02.11.04.015; 17.02.04.008; 24.06.02.0120.000161%
Vision blurred06.02.06.007; 17.17.01.0100.000322%
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