Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Phenylpropanolamine
Drug ID BADD_D01764
Description Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes.
Indications and Usage For the treatment of nasal congestion, control of urinary incontinence, priapism and obesity.
Marketing Status approved; vet_approved; withdrawn
ATC Code R01BA01
DrugBank ID DB00397
KEGG ID D08368
MeSH ID D010665
PubChem ID 4786
TTD Drug ID D09JXM
NDC Product Code 63083-1534
UNII 33RU150WUN
Synonyms Phenylpropanolamine | Norephedrine | Propagest | Phenylpropanolamine Hydrochloride | Hydrochloride, Phenylpropanolamine | Prolamine | Triaminic DM | Dexatrim
Chemical Information
Molecular Formula C9H13NO
CAS Registry Number 14838-15-4
SMILES CC(C(C1=CC=CC=C1)O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation17.02.05.012; 19.06.02.001--
Anxiety19.06.02.002--
Arrhythmia02.03.02.001---
Ataxia08.01.02.004; 17.02.02.001--
Blood pressure increased13.14.03.005---
Confusional state17.02.03.005; 19.13.01.001--
Constipation07.02.02.001--
Coordination abnormal17.02.02.004---
Dermatitis23.03.04.002---
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Dyskinesia17.01.02.006--
Dysphoria19.04.02.004---
Dyspnoea02.11.05.003; 22.02.01.004--
Euphoric mood19.04.02.006--
Feeling abnormal08.01.09.014---
Flushing08.01.03.025; 23.06.05.003; 24.03.01.002--
Hallucination19.10.04.003--
Hepatocellular injury09.01.07.008---
Hypersensitivity10.01.03.003--
Hypotension24.06.03.002--
Insomnia17.15.03.002; 19.02.01.002--
Irritability08.01.03.011; 19.04.02.013--
Nausea07.01.07.001--
Nervousness19.06.02.003---
Rash23.03.13.001---
Renal tubular necrosis20.01.07.003---
Respiratory depression17.02.05.047; 22.02.01.010---
Serotonin syndrome12.03.01.041; 15.05.04.016; 17.05.02.004---
Somnolence17.02.04.006; 19.02.05.003--
Tachycardia02.03.02.007---
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