Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Serotonin syndrome
ADR ID BADD_A03974
ADR Hierarchy
17      Nervous system disorders
17.05      Neuromuscular disorders
17.05.02      Muscle tone abnormal
17.05.02.004      Serotonin syndrome
12      Injury, poisoning and procedural complications
12.03      Exposures, chemical injuries and poisoning
12.03.01      Poisoning and toxicity
12.03.01.041      Serotonin syndrome
15      Musculoskeletal and connective tissue disorders
15.05      Muscle disorders
15.05.04      Muscle tone abnormalities
15.05.04.016      Serotonin syndrome
Description An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor. [MeSH]
MedDRA Code 10040108
MeSH ID D020230
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Serotonin syndrome | Serotonin Syndrome | Serotonin Syndromes | Syndrome, Serotonin | Syndromes, Serotonin
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00023Acetaminophen--
BADD_D00077Almotriptan--
BADD_D00085Alprazolam0.000107%
BADD_D00097Amantadine0.000393%
BADD_D00118Amitriptyline0.000048%
BADD_D00119Amitriptyline hydrochloride--
BADD_D00165Aripiprazole0.000911%
BADD_D00172Asenapine0.000861%
BADD_D00180Atomoxetine0.000232%
BADD_D00293Brexpiprazole0.000131%
BADD_D00310Buprenorphine0.000724%
BADD_D00311Buprenorphine hydrochloride--
BADD_D00312Bupropion0.001356%
BADD_D00316Buspirone--
BADD_D00317Buspirone hydrochloride--
BADD_D00356Carbamazepine0.000372%
BADD_D00369Cariprazine0.000131%
BADD_D00475Citalopram0.000165%
BADD_D00499Clomipramine--
BADD_D00501Clonazepam0.000089%
BADD_D00511Clozapine--
BADD_D00516Codeine0.000515%
BADD_D00545Cyclobenzaprine0.000016%
BADD_D00621Desvenlafaxine0.000802%
BADD_D00638Dextromethorphan--
BADD_D00648Diazepam0.000227%
BADD_D00734Duloxetine0.000932%
BADD_D00735Duloxetine hydrochloride--
BADD_D00755Eletriptan0.000361%
BADD_D00809Escitalopram0.000814%
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