Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Drug tolerance
ADR ID BADD_A05198
ADR Hierarchy
08      General disorders and administration site conditions
08.06      Therapeutic and nontherapeutic effects (excl toxicity)
08.06.01      Therapeutic and nontherapeutic responses
08.06.01.003      Drug tolerance
Description Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL. [MeSH]
MedDRA Code 10052804
MeSH ID D004361
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Habituation | Tendency of drug tolerance | Tolerance | Tolerance development | Drug tolerance | Drug Tolerance | Drug Tolerances | Tolerance, Drug | Tolerances, Drug
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00014Abiraterone0.000734%
BADD_D00044Adefovir dipivoxil0.000706%
BADD_D00047Afatinib0.000112%
BADD_D00085Alprazolam0.000200%
BADD_D00142Anastrozole0.000159%
BADD_D00167Armodafinil0.001692%
BADD_D00195Azathioprine--
BADD_D00199Azelastine hydrochloride--
BADD_D00209Baclofen0.000070%
BADD_D00330Cabozantinib0.000817%
BADD_D00475Citalopram--
BADD_D00501Clonazepam0.000267%
BADD_D00648Diazepam0.000111%
BADD_D00680Dimethyl fumarate--
BADD_D00686Diphenhydramine--
BADD_D00932Fluoxetine--
BADD_D00947Fluticasone propionate--
BADD_D00979Furosemide0.000035%
BADD_D00981Gabapentin0.000112%
BADD_D01008Gefitinib0.000112%
BADD_D01096Hydromorphone0.000370%
BADD_D01136Imatinib0.000246%
BADD_D01317Loratadine--
BADD_D01318Lorazepam0.000114%
BADD_D01368Mefenamic acid0.002974%
BADD_D01369Mefloquine--
BADD_D01405Methadone0.000583%
BADD_D01418Methotrexate0.000967%
BADD_D01431Methylphenidate0.000160%
BADD_D01476Mirtazapine--
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ADReCS-Target
ADR Term Drug Name Target