Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Tachyphylaxis
ADR ID BADD_A04231
ADR Hierarchy
08      General disorders and administration site conditions
08.06      Therapeutic and nontherapeutic effects (excl toxicity)
08.06.01      Therapeutic and nontherapeutic responses
08.06.01.028      Tachyphylaxis
10      Immune system disorders
10.02      Immune disorders NEC
10.02.01      Immune and associated conditions NEC
10.02.01.050      Tachyphylaxis
Description Rapidly decreasing response to a drug or physiologically active agent after administration of a few doses. In immunology, it is the rapid immunization against the effect of toxic doses of an extract or serum by previous injection of small doses. (Dorland, 28th ed) [MeSH]
MedDRA Code 10043087
MeSH ID D013618
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Tachyphylaxis
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00086Alprostadil--
BADD_D00648Diazepam0.000050%
BADD_D00898Finasteride--
BADD_D01418Methotrexate--
BADD_D01579Nitroglycerin0.000065%
BADD_D01864Propofol0.000268%
BADD_D02079Succinylcholine--
BADD_D02422Cisatracurium0.000194%
BADD_D02467Naloxegol0.001493%
BADD_D02488Esketamine0.000315%
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