| Drug Name |
Nitroglycerin |
| Drug ID |
BADD_D01579 |
| Description |
Nitroglycerin is a vasodilator drug used for the treatment of chest pain and high blood pressure.[T628,L4429] It was first approved in 2000 and is currently marketed by Pfizer, and other companies, depending on the dosage form.[T628,L4894] Nitroglycerin is available in various forms, including a spray form, sublingual tablet form, intravenous form, extended-release tablet form, and transdermal form. A less commonly known fact is that in addition to treating angina, nitroglycerin is also used in an ointment to treat the pain that accompanies anal fissures. The rectal ointment form of nitroglycerin was approved by the FDA in 1955.[L7096] |
| Indications and Usage |
Nitroglycerin is indicated for various purposes.[L4894] It is indicated to prevent and treat angina or chest pain due to cardiovascular disease, as well as to treat peri-operative hypertension or induce intra-operative hypotension.[L4429,L7099] It is also indicated to treat acute heart failure in patients with myocardial infarction.[L7099] In the ointment form, nitroglycerin is indicated to treat pain caused by anal fissures.[L7096] The transdermal form is applied directly to the skin to prevent acute anginal attacks.[L7141]
The intravenous form is used off-label in emergency settings and is commonly used to treat acute coronary spasm caused by cocaine, hypertensive emergencies, as well as acute congestive heart failure exacerbations.[T628] Some other off-label uses of nitroglycerin include management of variceal hemorrhage[A180280], management of esophageal spasticity[A180283], and induction of uterine relaxation.[A180277] |
| Marketing Status |
approved; investigational |
| ATC Code |
C05AE01; C01DA02 |
| DrugBank ID |
DB00727
|
| KEGG ID |
D00515
|
| MeSH ID |
D005996
|
| PubChem ID |
4510
|
| TTD Drug ID |
D07YDE
|
| NDC Product Code |
47781-457; 47781-458; 50742-513; 59762-3304; 63629-8830; 0378-9104; 0378-9116; 68428-407; 70710-1019; 70771-1718; 70771-1719; 43598-895; 45802-210; 49483-221; 50090-4874; 52584-418; 0338-1047; 68428-100; 71205-482; 71872-7010; 28595-120; 51662-1351; 51662-1386; 0404-9928; 68071-2260; 68071-2941; 68462-640; 70518-0545; 59762-0489; 0338-1051; 63629-8829; 68428-050; 70710-1018; 72888-138; 43598-435; 43598-436; 47781-456; 49483-223; 50742-518; 51662-1244; 52584-810; 60429-839; 0404-9929; 69339-173; 71872-7201; 72888-139; 43598-893; 50090-0332; 0220-2291; 50742-516; 60429-840; 60429-841; 68462-638; 72888-140; 0071-0417; 0071-0418; 43598-896; 58914-301; 63187-884; 0378-9112; 70771-1717; 71205-225; 0071-0419; 50090-3266; 50742-514; 50742-515; 0338-1049; 63629-8828; 69339-174; 70710-1020; 71872-7300; 0220-2283; 51662-1282; 51662-1340; 64117-543; 68462-639; 69339-175; 0517-4810; 28595-550; 43598-437; 43598-894; 49483-222; 50742-517; 0378-9102; 71872-7033; 0281-0326; 59762-4921 |
| UNII |
G59M7S0WS3
|
| Synonyms |
Nitroglycerin | Glyceryl Trinitrate | Trinitrate, Glyceryl | Nitrolan | Nitrospan | Nitrostat | Perlinganit | Nitrong | Susadrin | Sustac | Sustak | Sustonit | Transderm Nitro | Nitroglyn | Trinitrin | Trinitrolong | Anginine | Dynamite | Gilustenon | Nitrangin | Nitro-Bid | Nitro Bid | NitroBid | Nitro-Dur | Nitro Dur | NitroDur | Nitrocard | Nitroderm | Nitroderm TTS | Nitrol | Tridil |
