Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Vilazodone
Drug ID BADD_D02456
Description Vilazodone is a novel compound with combined high affinity and selectivity for the 5-hydroxytryptamine (5-HT) transporter and 5-HT(1A) receptors[Label,A177622]. Vilazodone may also be associated with less sexual dysfunction and weight gain[A6947]. Vilazodone was given FDA approval on January 21, 2011[L6046,A177622].
Indications and Usage Vilazodone is approved for treatment of acute episodes of major depression. Labeling of vilazodone describes an increased risk of suicidal thoughts in children, adolescents and young adults. The use of vilazodone in pediatrics is not indicated. Its use with monoamine oxidase inhibitors (MAOI) is contraindicated due to increased risk of serotonin syndome. Once the MAOI is discontinued, a 14-day washout period must pass before starting vilazodone.
Marketing Status Not Available
ATC Code N06AX24
DrugBank ID DB06684
KEGG ID D09698
MeSH ID D000069503
PubChem ID 6918314
TTD Drug ID D0X6BV
NDC Product Code Not Available
Synonyms Vilazodone Hydrochloride | Hydrochloride, Vilazodone | 2-benzofurancarboxamide, 5-(4-(4-(5-cyano-1H-indol-3-yl)butyl)-1-piperazinyl)-, hydrochloride (1:1) | Vilazodone HCl | HCl, Vilazodone | Viibryd | EMD 68843 | 68843, EMD | EMB-68843 | EMB 68843 | EMB68843 | Vilazodone | 5-(4-(4-(5-cyano-3-indolyl)butyl)-1-piperazinyl)benzofuran-2-carboxamide
Chemical Information
Molecular Formula C26H27N5O2
CAS Registry Number 163521-12-8
SMILES C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=C5)C(=O)N
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.005939%Not Available
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Abnormal dreams17.15.02.001; 19.02.03.0010.024499%Not Available
Acne23.02.01.0010.001485%Not Available
Ageusia07.14.03.003; 17.02.07.0010.001485%Not Available
Aggression19.05.01.0010.006682%Not Available
Agitation17.02.05.012; 19.06.02.0010.013363%
Alopecia23.02.02.0010.006682%
Altered state of consciousness17.02.04.001; 19.07.01.0030.001485%Not Available
Amnesia17.03.02.001; 19.20.01.0010.004454%
Anger19.04.02.0010.004454%Not Available
Anxiety19.06.02.0020.023757%
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Blood cholesterol increased13.12.01.0020.002227%
Blood creatinine increased13.13.01.004--
Blood glucose increased13.02.02.0020.004454%Not Available
Blood pressure increased13.14.03.0050.006682%Not Available
Blood triglycerides increased13.12.03.0010.001485%Not Available
Bruxism07.01.06.008; 19.11.03.0010.001485%Not Available
C-reactive protein increased13.09.01.0070.001485%Not Available
Cerebral haemorrhage17.08.01.003; 24.07.04.001--Not Available
Cerebrovascular accident17.08.01.007; 24.03.05.001--
Chest discomfort02.02.02.009; 08.01.08.019; 22.02.08.001--Not Available
Chest pain02.02.02.011; 08.01.08.002; 22.02.08.003--Not Available
Completed suicide08.04.01.010; 19.12.01.0010.003680%Not Available
Confusional state17.02.03.005; 19.13.01.0010.007424%
Constipation07.02.02.001--
Coordination abnormal17.02.02.0040.002227%Not Available
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