Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Vilazodone
Drug ID BADD_D02456
Description Vilazodone is a novel compound with combined high affinity and selectivity for the 5-hydroxytryptamine (5-HT) transporter and 5-HT(1A) receptors[Label,A177622]. Vilazodone may also be associated with less sexual dysfunction and weight gain[A6947]. Vilazodone was given FDA approval on January 21, 2011[L6046,A177622].
Indications and Usage Vilazodone is approved for treatment of major depressive disorder.[Label,A38477,A177622]
Marketing Status approved
ATC Code N06AX24
DrugBank ID DB06684
KEGG ID D09698
MeSH ID D000069503
PubChem ID 6918314
TTD Drug ID D0X6BV
NDC Product Code Not Available
UNII S239O2OOV3
Synonyms Vilazodone Hydrochloride | Hydrochloride, Vilazodone | 2-benzofurancarboxamide, 5-(4-(4-(5-cyano-1H-indol-3-yl)butyl)-1-piperazinyl)-, hydrochloride (1:1) | Vilazodone HCl | HCl, Vilazodone | Viibryd | EMD 68843 | 68843, EMD | EMB-68843 | EMB 68843 | EMB68843 | Vilazodone | 5-(4-(4-(5-cyano-3-indolyl)butyl)-1-piperazinyl)benzofuran-2-carboxamide
Chemical Information
Molecular Formula C26H27N5O2
CAS Registry Number 163521-12-8
SMILES C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=C5)C(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.004281%-
Abdominal distension07.01.04.0010.001246%
Abnormal dreams17.15.02.001; 19.02.03.0010.013576%-
Acne23.02.01.0010.001246%-
Ageusia07.14.03.003; 17.02.07.0010.001246%-
Aggression19.05.01.0010.004281%-
Agitation17.02.05.012; 19.06.02.0010.008337%
Akathisia17.01.02.002; 19.06.02.0060.000703%
Alopecia23.02.02.0010.005367%
Altered state of consciousness17.02.04.001; 19.07.01.0030.000319%-
Amnesia17.03.02.001; 19.20.01.0010.001342%
Anger19.04.02.0010.002651%-
Anosmia17.04.04.001; 22.04.03.0060.000703%
Anxiety19.06.02.0020.013512%
Aura17.02.07.0110.000703%-
Bladder discomfort20.02.02.0190.001086%-
Breast tenderness21.05.05.0040.000703%-
Bruxism07.01.06.008; 19.11.03.0010.000319%-
Chest discomfort02.02.02.009; 08.01.08.019; 22.12.02.0020.002172%-
Completed suicide08.04.01.010; 19.12.01.0010.003674%-
Confusional state17.02.03.005; 19.13.01.0010.003674%
Coordination abnormal17.02.02.0040.000862%-
Crying08.01.03.005; 12.02.11.001; 17.02.05.013; 19.04.02.0020.003833%-
Delirium19.13.02.0010.000319%
Depressed mood19.15.02.0010.000703%-
Depression19.15.01.0010.007826%
Diabetic ketoacidosis05.07.03.001; 14.07.03.0010.000319%-
Diarrhoea07.02.01.0010.028494%
Diarrhoea haemorrhagic07.02.01.002; 24.07.02.0040.000319%-
Disorientation17.02.05.015; 19.13.01.0020.000639%-
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