Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cinacalcet
Drug ID BADD_D02434
Description Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia and as Mimpara® in Europe. It is used to treat hyperparathyroidism due to parathyroid tumours or renal failure.
Indications and Usage For the treatment of secondary hyperparathyroidism in patients with Chronic Kidney Disease who are on hemodialysis or peritoneal dialysis. Also for the treatment of hypercalcemia in patients with parathyroid carcinoma.
Marketing Status approved
ATC Code H05BX01
DrugBank ID DB01012
KEGG ID D03504
MeSH ID D000069449
PubChem ID 156419
TTD Drug ID D03YGR
NDC Product Code 72865-150; 72865-151; 72865-152; 42291-459; 65862-832; 16714-080; 42291-461; 67877-504; 68180-228; 42543-962; 47335-600; 51407-297; 63629-8765; 63629-8764; 63629-9607; 64380-885; 67877-503; 69097-410; 69097-412; 47335-380; 50268-153; 51407-296; 76282-674; 76282-675; 16729-440; 16729-441; 31722-104; 65162-155; 65162-213; 67877-505; 42291-460; 42543-961; 43598-368; 65162-157; 65862-831; 69097-411; 43598-369; 63629-8763; 63629-9606; 63629-9608; 65862-833; 68180-226; 31722-103; 47335-379; 60687-525; 64380-883; 68180-227; 76282-676; 0904-7067; 31722-105; 43598-367; 64380-884; 16729-442; 42543-963; 51407-295
UNII UAZ6V7728S
Synonyms Cinacalcet | Cinacalcet Hydrochloride | Alpha-methyl-N-(3-(3-(trifluoromethyl)phenyl)propyl)-1-naphthalenemethanamine, (alphaR)-hydrochloride | Sensipar | AMG 073 | KRN 1493 | AMG073
Chemical Information
Molecular Formula C22H22F3N
CAS Registry Number 226256-56-0
SMILES CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.265427%-
Abdominal pain upper07.01.05.0030.177121%
Abdominal rigidity07.01.05.0110.001329%-
Abnormal sensation in eye06.01.01.0010.000860%-
Aortic dissection24.02.03.0020.000391%-
Arrhythmia02.03.02.0010.028654%-
Azotaemia20.01.01.0010.000391%-
Back disorder15.03.05.0030.004183%-
Bone pain15.02.01.0010.019311%
Cachexia08.01.01.009; 14.03.02.001; 16.32.03.0110.000586%-
Calcinosis08.03.04.0020.000977%-
Cardiovascular disorder02.11.01.010; 24.03.02.0090.003362%-
Carpal tunnel syndrome17.09.02.0010.001525%-
Cerebral thrombosis17.08.01.006; 24.01.04.0030.000391%-
Constipation07.02.02.0010.106249%
Death08.04.01.0010.173759%
Defaecation urgency07.02.04.0010.001329%-
Diabetic neuropathy05.07.04.003; 14.07.04.003; 17.09.04.0020.000860%-
Diarrhoea07.02.01.0010.351818%
Duodenitis07.08.03.0010.000391%-
Dyspepsia07.01.02.0010.032602%
Dysphagia07.01.06.0030.064226%
Eating disorder14.03.01.008; 19.09.01.0080.011024%-
Eructation07.01.02.0030.003714%
Faeces discoloured07.01.03.0020.011415%-
Faeces hard07.01.03.0030.001329%-
Fistula15.03.02.0010.003831%-
Flatulence07.01.04.0020.013682%
Food allergy10.01.01.0120.000860%-
Formication17.02.06.018; 19.10.04.0020.003323%-
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