Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Foscarnet
Drug ID BADD_D02421
Description An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV.
Indications and Usage For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients.
Marketing Status approved
ATC Code J05AD01
DrugBank ID DB00529
KEGG ID D00579; D02267
MeSH ID D017245
PubChem ID 3415
TTD Drug ID D0OT0O
NDC Product Code Not Available
UNII 364P9RVW4X
Synonyms Foscarnet | Phosphonoformic Acid | Foscarnet Trisodium Salt | Foscarnet Calcium (2:3) Salt | Foscarnet Disodium Salt | Foscarnet Magnesium (2:3) Salt | Trisodium Phosphonoformate | Phosphonoformate | Foscarnet Sodium | Foscarnet Trilithium Salt | Foscarnet Tripotassium Salt | Foscarnet Sodium Hexahydrate | Foscavir | Foscarnet Barium (2:3) Salt | Foscarnet Manganese (2+) (2:3) Salt
Chemical Information
Molecular Formula CH3O5P
CAS Registry Number 4428-95-9
SMILES C(=O)(O)P(=O)(O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Renal failure20.01.03.0050.001552%-
Renal tubular acidosis14.01.01.005; 20.05.03.0030.000423%-
Renal tubular disorder20.05.03.0040.000282%-
Respiratory failure14.01.04.003; 22.02.06.0020.000282%
Retinal detachment06.09.03.003; 12.01.04.0040.000423%
Seizure17.12.03.0010.000423%
Shock24.06.02.0020.000423%-
Status epilepticus17.12.03.0050.000282%-
Thrombotic microangiopathy01.01.02.006; 20.01.07.004; 24.01.01.0130.000282%-
Visual acuity reduced06.02.10.012; 17.17.01.0110.000282%
General physical health deterioration08.01.03.0180.000423%-
Foetal death08.04.01.011; 18.01.02.0030.000282%
Drug resistance08.06.01.0050.000423%-
Disease progression08.01.03.0380.000565%
Renal impairment20.01.03.0100.001835%-
Bone marrow failure01.03.03.0050.000282%
Treatment failure08.06.01.0170.000762%-
Acute kidney injury20.01.03.0160.001694%
Posterior reversible encephalopathy syndrome17.13.02.0070.000282%
Multiple organ dysfunction syndrome08.01.03.0570.000706%
Drug ineffective for unapproved indication08.06.01.038; 12.09.02.0020.000621%-
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