Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ropivacaine
Drug ID BADD_D02416
Description Ropivacaine is an aminoamide local anaesthetic drug commonly marketed by AstraZeneca under the trade name Naropin. It is present as a racemic mixture of the enantiomers containing equal proportions of the “S” and “R” forms. The marketed form contains the single S-enantiomer as the active ingredient.
Indications and Usage Used in obstetric anesthesia and regional anesthesia for surgery.
Marketing Status approved
ATC Code N01BB09
DrugBank ID DB00296
KEGG ID D08490
MeSH ID D000077212
PubChem ID 175805
TTD Drug ID D09RHQ
NDC Product Code 76339-126; 29902-0022
UNII 7IO5LYA57N
Synonyms Ropivacaine | 1-Propyl-2',6'-pipecoloxylidide | 1 Propyl 2',6' pipecoloxylidide | Naropin | Ropivacaine Monohydrochloride | Ropivacaine Hydrochloride | AL 381 | AL-381 | AL381 | Naropeine | LEA 103 | LEA-103 | LEA103 | Ropivacaine Monohydrochloride, (S)-isomer
Chemical Information
Molecular Formula C17H26N2O
CAS Registry Number 84057-95-4
SMILES CCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaphylactic reaction10.01.07.001; 24.06.03.0060.000179%
Anaphylactic shock10.01.07.002; 24.06.02.0040.000179%-
Aphonia17.02.08.009; 19.19.01.002; 22.12.03.0010.000179%
Apnoea22.02.01.0010.000179%
Arthropathy15.01.01.0030.005037%-
Atrial tachycardia02.03.03.0040.000179%
Blindness06.02.10.003; 17.17.01.0030.000179%-
Bradycardia02.03.02.0020.000447%-
Cardiac arrest02.03.04.0010.001018%
Cardiogenic shock02.05.01.003; 24.06.02.0060.000179%-
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.0030.000179%-
Circulatory collapse24.06.02.0010.000179%-
Coma17.02.09.0010.000179%-
Cyanosis02.11.04.004; 22.02.02.007; 23.06.04.005; 24.03.01.0070.000179%
Diaphragmatic paralysis17.01.04.014; 22.09.02.0020.000179%-
Diplegia17.01.04.0150.000179%-
Drug ineffective08.06.01.0060.023221%-
Dysgeusia07.14.03.001; 17.02.07.0030.001000%
Dyskinesia17.01.02.0060.001608%
Dysphoria19.04.02.0040.000179%-
Dyspnoea02.11.05.003; 22.02.01.0040.000714%
Generalised tonic-clonic seizure17.12.01.0020.000536%-
Horner's syndrome06.09.04.002; 16.32.03.006; 17.05.01.0040.000179%-
Hypoaesthesia17.02.06.023; 23.03.03.0810.006216%-
Hypotension24.06.03.0020.000357%
Hypoxia22.02.02.0030.000179%
Loss of consciousness17.02.04.0040.000357%-
Movement disorder17.01.02.0100.004519%-
Muscular weakness15.05.06.001; 17.05.03.0050.000875%
Nervous system disorder17.02.10.0010.000179%-
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ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene