Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Unoprostone
Drug ID BADD_D02316
Description Unoprostone isopropyl is a prostaglandin analogue. Ophthalmic Solution 0.15% is a synthetic docosanoid. Unoprostone isopropyl has the chemical name isopropyl (+)-(Z)-7-[(1R,2R,3R,5S)-3,5 dihydroxy-2-(3-oxodecyl)cyclopentyl]-5-heptenoate. The main indication of Unoprostane is treatment of glucoma.
Indications and Usage For the lowering of intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are intolerant of other intraocular pressure lowering medications or insufficiently responsive (failed to achieve target IOP determined after multiple measurements over time) to another intraocular pressure lowering medication.
Marketing Status approved; investigational
ATC Code S01EE02
DrugBank ID DB06826
KEGG ID D08661
MeSH ID C072630
PubChem ID 5311236
TTD Drug ID Not Available
NDC Product Code Not Available
UNII 6X4F561V3W
Synonyms isopropyl unoprostone | unoprostone isopropyl | isopropyl Z-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl)cyclopentyl)hept-5-enoate, D- | isopropyl 20-ethyl-9alpha,11alpha-dihydroxy-15-keto-cis-delta-5-prostanoate | Rescula | Eescula | UF 021 | UF-021
Chemical Information
Molecular Formula C22H38O5
CAS Registry Number 120373-36-6
SMILES CCCCCCCC(=O)CCC1C(CC(C1CC=CCCCC(=O)O)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Back pain15.03.04.005--
Blepharitis06.04.04.001; 23.03.04.012---
Bronchitis11.01.09.001; 22.07.01.001--
Cataract06.06.01.001--
Colour blindness03.01.01.001; 06.02.09.001---
Conjunctival oedema06.04.01.001---
Conjunctivitis06.04.01.002; 11.01.06.012--
Corneal deposits06.06.03.002---
Corneal erosion06.06.03.003---
Corneal lesion06.06.03.004---
Corneal oedema06.04.02.001---
Corneal opacity06.06.03.005---
Cough22.02.03.001--
Diabetes mellitus05.06.01.001; 14.06.01.001---
Diplopia06.02.06.002; 17.17.01.005---
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Dry eye06.08.02.001--
Dry mouth07.06.01.002--
Eye haemorrhage06.07.02.001; 12.02.02.012; 24.07.05.002---
Eye pain06.08.03.002--
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Injury12.01.08.004---
Insomnia17.15.03.002; 19.02.01.002--
Iritis06.04.03.002; 10.02.01.022---
Keratitis06.04.02.002--
Nausea07.01.07.001--
Optic atrophy06.09.02.001---
Pain08.01.08.004--
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