Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Treprostinil
Drug ID BADD_D02268
Description Treprostinil is a synthetic analogue of prostacyclin, used to treat pulmonary hypertension.
Indications and Usage For use as a continuous subcutaneous infusion or intravenous infusion (for those not able to tolerate a subcutaneous infusion) for the treatment of pulmonary arterial hypertension in patients with NYHA Class II-IV symptoms to diminish symptoms associated with exercise.
Marketing Status approved; investigational
ATC Code B01AC21
DrugBank ID DB00374
KEGG ID D06213
MeSH ID C427248
PubChem ID 6918140
TTD Drug ID D01WUA
NDC Product Code 0703-0696; 0781-3430; 11014-0094; 66302-350; 66302-648; 66302-748; 66302-361; 66302-363; 66302-620; 66302-720; 0703-0676; 43598-646; 43598-647; 66302-302; 66302-325; 66302-616; 66302-362; 0703-0666; 14501-0015; 42023-209; 62332-515; 66302-110; 66302-300; 66302-610; 54893-0024; 43598-649; 62332-514; 62332-517; 66302-102; 66302-206; 66302-732; 58159-041; 68245-0008; 43598-648; 66302-120; 66302-600; 66302-650; 66302-764; 0703-0686; 0781-3420; 0781-3425; 81861-0029; 66302-101; 66302-310; 66302-630; 66302-664; 0781-3427; 42023-206; 66302-105; 66302-640; 42023-207; 62332-516; 66302-632; 66302-716; 42023-208
UNII RUM6K67ESG
Synonyms treprostinil | ((1R,2R,3AS,9AS)-2-hydroxy-1-((3S)-3-hydroxyoctyl)-2,3,3A,4,9,9A-hexahydro-1H-cylopent(b)naphthalen-5-yl)oxy)acetate | treprostinil sodium | trepostinil sodium | Orenitram | UT-15 | UT-15C | Remodulin | treprostinil diolamine | treprostinil diolamin | treprostinil diethanolamine
Chemical Information
Molecular Formula C23H34O5
CAS Registry Number 81846-19-7
SMILES CCCCCC(CCC1C(CC2C1CC3=C(C2)C(=CC=C3)OCC(=O)O)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Ventricular arrhythmia02.03.04.0060.000082%
Viral infection11.05.04.001---
Vomiting07.01.07.0030.018242%
Vomiting projectile07.01.07.0120.000280%-
Wheezing22.03.01.0090.001867%
Withdrawal hypertension08.06.02.007; 24.08.02.0090.000082%-
Mental status changes19.07.01.0010.000864%-
Mobility decreased08.01.03.030; 15.03.05.023; 17.02.05.0180.001086%-
Fibromyalgia15.05.02.0020.000280%-
Infusion site erythema08.02.05.008; 12.07.05.009; 23.03.06.0160.009343%-
Seasonal allergy06.04.01.013; 10.01.04.001; 22.04.04.0080.001439%-
Peripheral swelling02.05.04.015; 08.01.03.0530.006456%-
Localised oedema02.05.04.006; 08.01.07.011; 14.05.06.0090.000666%
Weight fluctuation14.03.02.0020.000321%-
Brain death08.04.01.004; 17.02.03.0030.000164%-
Sudden cardiac death02.03.04.016; 08.04.01.0080.000206%-
General physical health deterioration08.01.03.0180.004096%-
Left ventricular hypertrophy02.04.02.0140.000181%-
Muscle tightness15.05.03.0070.000559%-
Dysstasia08.01.03.089; 15.03.05.011; 17.02.02.0120.000502%-
Contusion12.01.06.001; 15.03.05.007; 23.03.11.002; 24.07.06.001--
Musculoskeletal chest pain15.03.04.012; 22.09.01.0010.000263%
Cardiopulmonary failure02.05.01.004; 22.02.06.0040.000164%-
Catheter site haemorrhage08.02.02.002; 12.07.02.002; 24.07.01.0030.000724%-
Exercise tolerance decreased08.01.03.0360.000765%-
Haemodynamic instability24.03.02.0060.000345%-
Ear discomfort04.03.01.0050.000263%-
Ocular discomfort06.08.03.0080.000419%-
Respiratory tract congestion22.02.07.0030.001949%-
Catheter site erythema08.02.02.003; 12.07.02.003; 23.03.06.0140.000362%-
The 10th Page    First    Pre   10 11 12 13 14    Next   Last    Total 15 Pages
ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene