ADReCS

Pharmaceutical Information

Drug Name	Tolterodine
Drug ID	BADD_D02244
Description	Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. Tolterodine acts on M2 and M3 subtypes of muscarinic receptors.
Indications and Usage	For the treatment of overactive bladder (with symptoms of urinary frequency, urgency, or urge incontinence).
Marketing Status	approved; investigational
ATC Code	G04BD07
DrugBank ID	DB01036
KEGG ID	D00646
MeSH ID	D000068737
PubChem ID	443879
TTD Drug ID	D0BZ7W
NDC Product Code	13668-189; 13668-190; 0904-6592; 60687-330; 0904-6593; 65427-022; 60687-319
UNII	WHE7A56U7K
Synonyms	Tolterodine Tartrate \| Tartrate, Tolterodine \| Tolterodine \| Detrol \| Detrol LA \| Urotrol \| PHA-686464B \| PHA 686464B \| PHA686464B \| Detrusitol \| Unidet

Chemical Information

Molecular Formula	C22H31NO
CAS Registry Number	124937-51-5
SMILES	CC1=CC(=C(C=C1)O)C(CCN(C(C)C)C(C)C)C2=CC=CC=C2
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Diarrhoea	07.02.01.001	-	-
Disorientation	17.02.05.015; 19.13.01.002	-	-	-
Dizziness	02.11.04.006; 17.02.05.003; 24.06.02.007	0.003890%
Drug hypersensitivity	10.01.01.001	0.014405%		-
Drug ineffective	08.06.01.006	0.019856%		-
Drug interaction	08.06.03.001	0.000498%		-
Dry eye	06.08.02.001	0.001153%
Dry mouth	07.06.01.002	0.003641%
Dry skin	23.03.03.001	-	-
Dyspepsia	07.01.02.001	-	-
Dysphagia	07.01.06.003	0.000995%
Dysuria	20.02.02.002	-	-
Eye disorder	06.08.03.001	-	-	-
Fatigue	08.01.01.002	-	-
Feeling abnormal	08.01.09.014	0.000882%		-
Flatulence	07.01.04.002	-	-
Flushing	08.01.03.025; 23.06.05.003; 24.03.01.002	0.000452%
Gait disturbance	08.01.02.002; 15.03.05.013; 17.02.05.016	0.000226%
Gastrooesophageal reflux disease	07.02.02.003	-	-
Gastrointestinal pain	07.01.05.005	-	-
Hallucination	19.10.04.003	-	-
Hallucination, visual	19.10.04.007	0.000226%		-
Headache	17.14.01.001	0.002103%
Hypersensitivity	10.01.03.003	-	-
Hypertension	24.08.02.001	0.000339%
Hypertonic bladder	17.10.01.003; 20.03.03.003	0.000498%		-
Infection	11.01.08.002	-	-	-
Influenza like illness	08.01.03.010	-	-
Joint swelling	15.01.02.004	0.000226%		-
Lip swelling	07.05.04.005; 10.01.05.005; 23.04.01.007	0.000339%		-

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