Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tacrine hydrochloride
Drug ID BADD_D02104
Description A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market.
Indications and Usage For the palliative treatment of mild to moderate dementia of the Alzheimer's type.
Marketing Status approved; investigational; withdrawn
ATC Code N06DA01
DrugBank ID DB00382
KEGG ID D02068
MeSH ID D013619
PubChem ID 2723754
TTD Drug ID D0E6YQ
NDC Product Code Not Available
UNII 4966RNG0BU
Synonyms Tacrine | 9-Amino-1,2,3,4-Tetrahydroacridine | 1,2,3,4-Tetrahydro-9-acridinamine | Tetrahydroaminoacridine | 1,2,3,4-Tetrahydroaminoacridine | Romotal | Tenakrin | THA | Cognex | Tacrine Hydrochloride
Chemical Information
Molecular Formula C13H15ClN2
CAS Registry Number 1684-40-8
SMILES C1CCC2=NC3=CC=CC=C3C(=C2C1)N.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bradykinesia17.01.02.004---
Breast cancer16.10.01.001; 21.05.01.003---
Breast pain21.05.05.003--
Bronchitis11.01.09.001; 22.07.01.001--
Bundle branch block02.03.01.009---
Burning sensation08.01.09.029; 17.02.06.001---
Bursitis12.04.03.010; 15.04.01.001---
Cachexia08.01.01.009; 14.03.02.001; 16.32.03.011---
Cardiac arrest02.03.04.001--
Cardiac failure02.05.01.001--
Cataract06.06.01.001--
Cellulitis11.02.01.001; 23.11.02.004---
Cerebrovascular accident17.08.01.007; 24.03.05.001--
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.003---
Cholecystitis09.03.01.001--
Cholelithiasis09.03.01.002---
Cholinergic syndrome17.05.01.002---
Cogwheel rigidity15.05.04.006; 17.01.05.001---
Coma17.02.09.001---
Confusional state17.02.03.005; 19.13.01.001--
Conjunctivitis06.04.01.002; 11.01.06.012--
Constipation07.02.02.001--
Conversion disorder19.24.01.001---
Cough22.02.03.001--
Cyst08.03.05.001; 16.02.02.002---
Cystitis11.01.14.001; 20.03.02.002--
Deafness04.02.01.001---
Death08.04.01.001--
Dehydration14.05.05.001--
Delirium19.13.02.001--
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