Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Cogwheel rigidity
ADR ID BADD_A00970
ADR Hierarchy
15      Musculoskeletal and connective tissue disorders
15.05      Muscle disorders
15.05.04      Muscle tone abnormalities
15.05.04.006      Cogwheel rigidity
17      Nervous system disorders
17.01      Movement disorders (incl parkinsonism)
17.01.05      Parkinson's disease and parkinsonism
17.01.05.001      Cogwheel rigidity
Description Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from MUSCLE SPASTICITY. (From Adams et al., Principles of Neurology, 6th ed, p73) [MeSH]
MedDRA Code 10009848
MeSH ID D009127
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Cogwheel rigidity | Rigidity cogwheel | Muscle Rigidity | Rigidity, Muscle | Rigidity, Muscular | Muscular Rigidity | Cogwheel Rigidity | Cogwheel Rigidities | Rigidities, Cogwheel | Rigidity, Cogwheel | Nuchal Rigidity | Rigidity, Nuchal | Extrapyramidal Rigidity | Rigidity, Extrapyramidal | Gegenhalten | Gegenhaltens | Catatonic Rigidity | Rigidity, Catatonic | Extensor Rigidity | Rigidity, Extensor
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00085Alprazolam0.000019%
BADD_D00165Aripiprazole0.000293%
BADD_D00166Aripiprazole lauroxil--
BADD_D00312Bupropion0.000050%
BADD_D00316Buspirone--
BADD_D00317Buspirone hydrochloride--
BADD_D00445Chlorpromazine--
BADD_D00511Clozapine0.001834%
BADD_D00648Diazepam0.000050%
BADD_D00734Duloxetine0.000027%
BADD_D00932Fluoxetine0.000053%
BADD_D01054Haloperidol--
BADD_D01303Lithium carbonate--
BADD_D01304Lithium cation0.000192%
BADD_D01305Lithium hydroxide--
BADD_D01330Lurasidone--
BADD_D01442Metoclopramide0.000196%
BADD_D01449Metronidazole0.000039%
BADD_D01599Olanzapine0.000210%
BADD_D01656Paliperidone0.011337%
BADD_D01657Paliperidone palmitate--
BADD_D01679Paroxetine--
BADD_D01680Paroxetine hydrochloride--
BADD_D01681Paroxetine hydrochloride hemihydrate--
BADD_D01682Paroxetine impurity a--
BADD_D01683Paroxetine mesylate--
BADD_D01774Pimozide--
BADD_D01835Pregabalin0.000078%
BADD_D01848Prochlorperazine--
BADD_D01951Risperidone0.001564%
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