Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Sulfasalazine
Drug ID BADD_D02093
Description A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see mesalamine) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
Indications and Usage For the treatment of Crohn's disease and rheumatoid arthritis as a second-line agent.
Marketing Status approved
ATC Code A07EC01
DrugBank ID DB00795
KEGG ID D00448
MeSH ID D012460
PubChem ID 5339
TTD Drug ID D02ZTJ
NDC Product Code 63629-5688; 49452-7523; 59116-0631; 0093-3234; 70518-0185; 51552-1044; 51927-0081; 50090-2013; 59762-5000; 62135-960; 70518-1829; 70518-3732; 0013-0102; 71610-577; 62705-0222; 62991-2704; 59762-0104; 70518-2342; 71610-706; 49964-0018; 57294-021; 50090-0086; 51927-0054; 59116-0632; 0591-0796; 23155-019; 0013-0101; 63629-9715; 38779-0176; 59116-0630; 59116-0633; 68022-7065
UNII 3XC8GUZ6CB
Synonyms Sulfasalazine | Salicylazosulfapyridine | Sulphasalazine | Salazosulfapyridine | Pyralin EN | Azulfadine | Azulfidine EN | Azulfidine | Asulfidine | Colo-Pleon | Colo Pleon | Pleon | Ulcol | Sulfasalazin medac | Sulfasalazin-Heyl | Sulfasalazin Heyl | Sulfasalazine FNA | Ucine | Salazopyrin | ratio-Sulfasalazine | ratio Sulfasalazine
Chemical Information
Molecular Formula C18H14N4O5S
CAS Registry Number 599-79-1
SMILES C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N=NC3=CC(=C(C=C3)O)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Enterocolitis07.08.03.0030.000303%
Eosinophilia01.02.04.0010.001818%
Eosinophilic myocarditis01.02.04.007; 02.04.03.0020.000455%-
Eosinophilic pneumonia01.02.04.003; 22.01.01.0040.001515%-
Erythema23.03.06.0010.002728%-
Erythema multiforme10.01.03.015; 23.03.01.003--
Eye disorder06.08.03.001---
Eye inflammation06.04.05.002---
Eye pain06.08.03.002--
Face oedema08.01.07.003; 10.01.05.002; 23.04.01.0040.001212%
Facial paralysis17.04.03.0080.000303%-
Factor II deficiency01.01.01.007; 03.15.01.004---
Faeces discoloured07.01.03.0020.000818%-
Febrile neutropenia01.02.03.002; 08.05.02.0040.001667%
Feeling jittery08.01.09.0160.001182%-
Fistula15.03.02.001---
Folate deficiency14.12.02.006---
Gait disturbance08.01.02.002; 15.03.05.013; 17.02.05.016--
Gamma-glutamyltransferase increased13.03.04.024--
Gastric ulcer07.04.03.0020.000303%
Gastrooesophageal reflux disease07.02.02.0030.001788%
Gastrointestinal disorder07.11.01.0010.017912%-
Gastrointestinal pain07.01.05.005--
Generalised oedema08.01.07.004; 14.05.06.0070.000303%
Glomerulonephritis10.02.01.006; 20.05.01.0010.000455%-
Glomerulonephritis rapidly progressive10.04.04.008; 20.05.01.0040.000303%-
Glossodynia07.14.02.0010.000818%-
Goitre05.02.01.001; 14.11.01.008---
Gout14.09.01.001; 15.01.06.001---
Granulocytopenia01.02.03.0030.000455%-
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ADReCS-Target
Drug Name ADR Term Target
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