Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Succinylcholine
Drug ID BADD_D02079
Description Succinylcholine is a depolarizing skeletal muscle relaxant consisting of two molecules of the endogenous neurotransmitter [acetylcholine] (ACh) linked by their acetyl groups.[A19054] It has been widely used for over 50 years,[A299] most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and surgical procedures. Its rapid onset and offset, with effects beginning within 60 seconds of intravenous administration and lasting between four to six minutes, make succinylcholine particularly useful in the setting of short medical procedures requiring brief periods of muscle relaxation.[L9004]
Indications and Usage Succinylcholine is indicated as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.[L9004]
Marketing Status approved
ATC Code M03AB01
DrugBank ID DB00202
KEGG ID D00766
MeSH ID D013390
PubChem ID 5314
TTD Drug ID D0Q7ZQ
NDC Product Code 43598-666; 71872-7241
UNII J2R869A8YF
Synonyms Succinylcholine | Succinyldicholine | Suxamethonium | Dicholine Succinate | Succinate, Dicholine | Quelicin | Succinylcholine Dichloride | Dichloride, Succinylcholine | Succinylcholine Dichloride, Di-H2O | Succinylcholine Dichloride, Di H2O | Succinylcholine Diiodide | Diiodide, Succinylcholine | Myorelaxin | Succinylcholine Diperchlorate | Diperchlorate, Succinylcholine | Succinylcholine Iodide | Suxamethonium Bromide | Bromide, Suxamethonium | Suxamethonium Chloride | Listenon | Succinylcholine Chloride | Anectine | Celocurine | Ditilin | Lysthenon | Succicuran | Succinylcholine Dibromide | Dibromide, Succinylcholine
Chemical Information
Molecular Formula C14H30N2O4+2
CAS Registry Number 306-40-1
SMILES C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Muscle spasms15.05.03.004--
Muscular weakness15.05.06.001; 17.05.03.0050.000154%
Myalgia15.05.02.0010.000251%
Myasthenia gravis10.04.05.001; 15.05.08.001; 17.05.04.001--
Myoglobinuria02.04.02.006; 15.05.03.009; 20.02.01.010---
Myoglobin urine present13.16.02.002---
Paralysis17.01.04.0040.000347%-
Pulmonary oedema02.05.02.003; 22.01.03.003--
Rash23.03.13.001---
Renal failure20.01.03.005---
Respiratory arrest22.02.01.0090.000057%-
Respiratory depression17.02.05.047; 22.02.01.0100.000057%-
Respiratory distress22.02.01.0120.000154%-
Respiratory failure14.01.04.003; 22.02.06.002--
Rhabdomyolysis15.05.05.0020.000154%
Salivary hypersecretion07.06.01.009---
Sedation17.02.04.0050.000057%-
Seizure17.12.03.0010.000256%
Shock24.06.02.002---
Sputum increased22.02.03.007---
Tachycardia02.03.02.0070.000182%-
Tachyphylaxis08.06.01.028; 10.02.01.050---
Therapeutic response decreased08.06.01.016---
Therapeutic response increased08.06.01.021---
Throat tightness19.01.02.005; 22.12.03.0310.000194%-
Trismus15.05.04.004; 17.01.03.004--
Urticaria10.01.06.001; 23.04.02.001--
Ventricular fibrillation02.03.04.008--
Ventricular tachycardia02.03.04.0100.000085%
Musculoskeletal discomfort15.03.04.001---
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ADReCS-Target
Drug Name ADR Term Target
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