Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Ropivacaine hydrochloride
Drug ID BADD_D01968
Description Ropivacaine is an aminoamide local anaesthetic drug commonly marketed by AstraZeneca under the trade name Naropin. It is present as a racemic mixture of the enantiomers containing equal proportions of the “S” and “R” forms. The marketed form contains the single S-enantiomer as the active ingredient.
Indications and Usage Used in obstetric anesthesia and regional anesthesia for surgery.
Marketing Status approved
ATC Code N01BB09
DrugBank ID DB00296
KEGG ID D04048
MeSH ID D000077212
PubChem ID 175804
TTD Drug ID D09RHQ
NDC Product Code 25021-671; 55150-197; 68083-263; 0409-9300; 70121-1734; 51552-1590; 0143-9263; 52584-286; 55150-201; 63323-286; 63323-288; 70069-063; 70121-1733; 70121-1735; 61876-0071; 43066-027; 0404-9924; 70069-067; 55150-196; 63323-285; 0409-9302; 70069-061; 70121-1732; 72572-707; 55150-200; 65145-107; 65145-108; 0409-9301; 70069-062; 76339-124; 17478-082; 43066-023; 0143-9266; 48954-722; 25021-652; 68083-262; 46014-1058; 49452-6303; 65372-1159; 17478-081; 0409-9303; 70069-064; 49386-025; 43066-015; 43066-019; 55150-198; 63323-287; 65145-109; 65145-110; 70069-065; 70069-066; 0143-9264; 0143-9265; 55150-195; 55150-199
UNII V910P86109
Synonyms Ropivacaine | 1-Propyl-2',6'-pipecoloxylidide | 1 Propyl 2',6' pipecoloxylidide | Naropin | Ropivacaine Monohydrochloride | Ropivacaine Hydrochloride | AL 381 | AL-381 | AL381 | Naropeine | LEA 103 | LEA-103 | LEA103 | Ropivacaine Monohydrochloride, (S)-isomer
Chemical Information
Molecular Formula C17H27ClN2O
CAS Registry Number 98717-15-8
SMILES CCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Body temperature decreased13.15.01.010---
Body temperature increased13.15.01.001---
Bradycardia02.03.02.002---
Bradycardia foetal02.03.02.018; 18.03.02.006---
Breast feeding26.05.01.001---
Bronchospasm10.01.03.012; 22.03.01.004--
Carbon dioxide increased13.02.01.011---
Cardiac arrest02.03.04.001--
Cardiac output decreased13.14.02.001---
Cauda equina syndrome17.10.03.006---
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.003---
Chills08.01.09.001; 15.05.03.016--
Coma17.02.09.001---
Confusional state17.02.03.005; 19.13.01.001--
Constipation07.02.02.001--
Cough22.02.03.001--
Depressed level of consciousness17.02.04.002--
Depression19.15.01.001--
Dermatitis23.03.04.002---
Diarrhoea07.02.01.001--
Discomfort08.01.08.003---
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Dysarthria17.02.08.001; 19.19.03.001--
Dyskinesia17.01.02.006--
Dyspepsia07.01.02.001--
Dyspnoea02.11.05.003; 22.02.01.004--
Dysuria20.02.02.002--
Electrocardiogram abnormal13.14.05.001---
Electrocardiogram ST segment13.14.05.035---
Electrocardiogram ST segment abnormal13.14.05.017---
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