Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Rasburicase
Drug ID BADD_D01917
Description Rasburicase is a recombinant urate-oxidase enzyme produced by a genetically modified Saccharomyces cerevisiae strain. The cDNA coding for rasburicase was cloned from a strain of _Aspergillus flavus_.
Indications and Usage For treatment of hyperuricemia, reduces elevated plasma uric acid levels (from chemotherapy)
Marketing Status Prescription
ATC Code V03AF07
DrugBank ID DB00049
KEGG ID D05704
MeSH ID C469709
PubChem ID Not Available
TTD Drug ID D08LJP
NDC Product Code 0024-5151; 0024-5150
Synonyms rasburicase | Elitek | Fasturtec
Chemical Information
Molecular Formula Not Available
CAS Registry Number 134774-45-1
SMILES Not Available
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Alanine aminotransferase increased13.03.01.003--
Anxiety19.06.02.002--
Arrhythmia supraventricular02.03.03.001--Not Available
Arthralgia15.01.02.001--
Constipation07.02.02.001--
Diarrhoea07.02.01.001--
Fluid overload02.05.04.004; 14.05.06.001--Not Available
Gastrointestinal infection07.19.02.005; 11.01.07.012--Not Available
Headache17.14.01.001--
Hyperbilirubinaemia01.06.04.003; 09.01.01.003; 14.11.01.010--Not Available
Hyperphosphataemia14.04.03.007--
Hypersensitivity10.01.03.003--
Hyperuricaemia14.09.01.003--
Hypophosphataemia14.04.03.001--
Injection site irritation08.02.03.027; 12.07.03.027--Not Available
Laryngeal pain22.02.05.036--
Leukaemia01.10.03.001; 16.01.03.001--
Lymphoma01.12.01.001; 16.20.01.001--Not Available
Mucosal inflammation08.01.06.002--Not Available
Myocardial ischaemia02.02.02.008; 24.04.04.010--Not Available
Nausea07.01.07.001--
Oedema peripheral02.05.04.007; 08.01.07.007; 14.05.06.011--
Pulmonary haemorrhage22.02.04.003; 24.07.01.016--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Respiratory failure14.01.04.003; 22.02.06.002--
Sepsis11.01.11.003--
Tumour lysis syndrome14.05.01.004; 16.32.03.002--
Vomiting07.01.07.003--
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ADReCS-Target
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