Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Raltegravir
Drug ID BADD_D01905
Description Raltegravir is an antiretroviral drug produced by Merck & Co., used to treat HIV infection. It received approval by the U.S. Food and Drug Administration (FDA) on 12 October 2007, the first of a new class of HIV drugs, the integrase inhibitors, to receive such approval.
Indications and Usage For the treatment of HIV-1 infection in conjunction with other antiretrovirals.
Marketing Status approved
ATC Code J05AJ01
DrugBank ID DB06817
KEGG ID D06676
MeSH ID D000068898
PubChem ID 54671008
TTD Drug ID D0I1FQ
NDC Product Code 0006-0477; 0006-3603; 50090-1085; 65977-0049; 82982-055; 17381-749; 0006-0227; 53002-1686; 71205-777; 68071-2113; 0006-3080; 0006-0473
UNII 22VKV8053U
Synonyms Raltegravir Potassium | Potassium, Raltegravir | Raltegravir | MK 0518 | 0518, MK | MK0518 | MK-0518 | Isentress
Chemical Information
Molecular Formula C20H21FN6O5
CAS Registry Number 518048-05-0
SMILES CC1=NN=C(O1)C(=O)NC(C)(C)C2=NC(=C(C(=O)N2C)O)C(=O)NCC3=CC=C(C=C3)F
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Amnestic disorder17.03.02.007; 19.20.05.0010.001648%-
Erectile dysfunction19.08.04.001; 21.03.01.0070.003626%
Renal injury12.01.05.001; 20.01.03.0150.003626%-
Ill-defined disorder08.01.03.0490.004120%-
Disease recurrence08.01.03.0500.001648%-
Renal impairment20.01.03.0100.006098%-
Sinus disorder22.04.06.0020.005604%
Chronic kidney disease20.01.03.0170.002472%
Immune reconstitution inflammatory syndrome08.06.02.014; 10.02.01.0430.009889%-
Suicidal behaviour19.12.01.006---
Treatment failure08.06.01.0170.008570%-
Low birth weight baby18.04.02.0030.006098%-
Head and neck cancer16.16.01.0030.002472%-
Hypertransaminasaemia09.01.02.0050.001648%-
Drug-induced liver injury09.01.07.023; 12.03.01.0440.011537%-
Drug reaction with eosinophilia and systemic symptoms10.01.01.021; 12.03.01.064; 23.03.05.0050.008240%-
Multiple organ dysfunction syndrome08.01.03.0570.002472%
Ureterolithiasis20.04.03.0030.001648%-
Alopecia areata10.04.02.011; 23.02.02.0080.003296%-
Vesicoureteric reflux20.03.05.0020.001648%-
Multiple-drug resistance08.06.01.0320.002472%-
Pyelocaliectasis20.01.06.0110.002472%-
Cerebral calcification17.11.01.0120.001648%-
Lenticulostriatal vasculopathy17.08.02.022; 18.04.04.009; 24.03.05.0130.001648%-
Poor feeding infant14.03.02.022; 18.04.06.0060.001648%-
Gait inability08.01.02.011; 17.02.05.0690.001648%-
Hydrocalyx20.01.05.0050.001648%-
Inhibitory drug interaction08.06.03.0140.001648%-
Kidney perforation20.01.02.0200.001648%-
Renal hypertrophy20.01.06.0170.002472%-
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ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene