Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Rabeprazole
Drug ID BADD_D01898
Description Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.
Indications and Usage For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.
Marketing Status approved; investigational
ATC Code A02BC04
DrugBank ID DB01129
KEGG ID D08463
MeSH ID D064750
PubChem ID 5029
TTD Drug ID D0KL4J
NDC Product Code 65162-724
UNII 32828355LL
Synonyms Rabeprazole | 2-((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methylsulfinyl)-1H-benzimidazole | Dexrabeprazole | E 3810 | E3810 | Pariet | Rabeprazole Sodium | Sodium, Rabeprazole | 1H-Benzimidazole, 2-(((4-(3-methoxypropoxy)-3-methyl-2-pyridinyl)methyl)sulfinyl)-, Sodium Salt | Aciphex | LY-307640 | LY 307640 | LY307640
Chemical Information
Molecular Formula C18H21N3O3S
CAS Registry Number 117976-89-3
SMILES CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCCCOC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Skin mass23.07.04.014---
Oropharyngeal pain07.05.05.004; 22.12.03.0160.000573%
Acute kidney injury20.01.03.0160.000911%
Functional gastrointestinal disorder07.11.01.016---
Drug-induced liver injury09.01.07.023; 12.03.01.0440.000911%-
Lacrimal structural disorder06.06.04.013---
Hepatic cancer09.04.02.008; 16.07.02.004---
Hepatocellular carcinoma09.04.02.010; 16.07.02.0050.000391%-
Drug reaction with eosinophilia and systemic symptoms10.01.01.021; 12.03.01.064; 23.03.05.0050.000391%-
Candida infection11.03.03.021--
Device related thrombosis08.07.05.001; 24.01.01.0270.000260%-
Abdominal mass07.01.01.003---
Adenocarcinoma gastric07.21.02.002; 16.13.03.0020.000260%-
Chronic gastritis07.08.02.005; 10.04.04.011; 11.07.01.0160.000391%-
Wernicke's encephalopathy14.12.02.013; 17.13.01.0130.000391%-
Richter's syndrome01.15.02.005; 16.28.02.0050.000260%-
Gastric mucosal lesion07.11.03.0070.000391%-
Gastrointestinal polyp haemorrhage07.20.01.011; 16.05.01.008; 24.07.02.0460.000521%-
End stage renal disease20.01.03.0190.000260%-
Heavy menstrual bleeding21.01.03.005---
Hypergastrinaemia07.11.03.0140.000260%-
Intermenstrual bleeding21.01.01.015---
Mucosal disorder08.01.06.029---
Pharyngeal swelling22.04.05.028---
Product intolerance08.06.01.045---
Taste disorder07.14.03.004; 17.02.07.029---
Therapeutic response changed08.06.01.059---
Therapy non-responder08.06.01.063---
Treatment noncompliance08.06.01.067; 12.09.02.0060.000573%-
Vulvovaginal inflammation21.14.02.014---
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