Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Wernicke's encephalopathy
ADR ID BADD_A07834
ADR Hierarchy
14      Metabolism and nutrition disorders
14.12      Vitamin related disorders
14.12.02      Water soluble vitamin deficiencies
14.12.02.013      Wernicke's encephalopathy
17      Nervous system disorders
17.13      Encephalopathies
17.13.01      Encephalopathies toxic and metabolic
17.13.01.013      Wernicke's encephalopathy
Description An acute neurological disorder characterized by the triad of ophthalmoplegia, ataxia, and disturbances of mental activity or consciousness. Eye movement abnormalities include nystagmus, external rectus palsies, and reduced conjugate gaze. THIAMINE DEFICIENCY and chronic ALCOHOLISM are associated conditions. Pathologic features include periventricular petechial hemorrhages and neuropil breakdown in the diencephalon and brainstem. Chronic thiamine deficiency may lead to KORSAKOFF SYNDROME. (Adams et al., Principles of Neurology, 6th ed, pp1139-42; Davis & Robertson, Textbook of Neuropathology, 2nd ed, pp452-3) [MeSH]
MedDRA Code 10047911
MeSH ID D014899
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Wernicke's encephalopathy | Wernicke's syndrome | Wernicke Encephalopathy | Encephalopathies, Wernicke | Wernicke Encephalopathies | Wernicke's Encephalopathy | Beriberi, Cerebral | Cerebral Beriberi | Encephalopathy, Wernicke | Encephalopathy, Gayet-Wernicke | Encephalopathy, Gayet Wernicke | Encephalopathy, Wernicke's | Encephalopathy, Wernickes | Wernicke Superior Hemorrhagic Polioencephalitis | Gayet-Wernicke Encephalopathy | Gayet Wernicke Encephalopathy | Wernicke Syndrome | Wernicke Disease | Wernicke Polioencephalitis, Superior Hemorrhagic | Wernicke's Disease | Wernicke's Superior Hemorrhagic Polioencephalitis | Wernicke's Syndrome | Wernicke's Polioencephalitis, Superior Hemorrhagic
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00169Arsenic trioxide0.000112%
BADD_D00474Cisplatin0.000168%
BADD_D00695Disulfiram0.003777%
BADD_D00979Furosemide0.000028%
BADD_D01449Metronidazole0.000039%
BADD_D01898Rabeprazole0.000391%
BADD_D02105Tacrolimus0.000446%
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