Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propylthiouracil
Drug ID BADD_D01869
Description A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)
Indications and Usage Used to manage hyperthyroidism which is due to an overactive thyroid gland (Grave's disease).
Marketing Status approved; investigational
ATC Code H03BA02
DrugBank ID DB00550
KEGG ID D00562
MeSH ID D011441
PubChem ID 657298
TTD Drug ID D00MIN
NDC Product Code 33342-314; 67253-651; 68084-964; 49452-6112; 20012-0001; 0228-2348; 70752-171; 59348-0013; 65319-1059
UNII 721M9407IY
Synonyms Propylthiouracil | 6-Propyl-2-Thiouracil | 6 Propyl 2 Thiouracil
Chemical Information
Molecular Formula C7H10N2OS
CAS Registry Number 51-52-5
SMILES CCCC1=CC(=O)NC(=S)N1
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Neutropenia01.02.03.0040.023510%-
Oedema08.01.07.006; 14.05.06.010---
Pancytopenia01.03.03.0030.014106%-
Paraesthesia17.02.06.005; 23.03.03.094--
Pleural effusion22.05.02.0020.014106%
Polyhydramnios18.05.01.0020.009404%-
Premature baby18.04.02.0010.023510%-
Premature delivery18.07.01.0060.009404%
Proteinuria20.02.01.0110.009404%
Pruritus23.03.12.001--
Pulmonary alveolar haemorrhage22.01.02.005; 24.07.01.0150.023510%-
Pyrexia08.05.02.003--
Rash23.03.13.001---
Rash erythematous23.03.13.029---
Respiratory failure14.01.04.003; 22.02.06.0020.018808%
Skin ulcer23.07.03.003; 24.04.03.007--
Somnolence17.02.04.006; 19.02.05.003--
Splenomegaly01.09.02.001---
Tachycardia02.03.02.0070.014106%-
Tachypnoea22.02.01.0140.009404%-
Thrombocytopenia01.08.01.002---
Thyroid disorder05.02.01.0020.009404%-
Thyrotoxic crisis05.02.02.004; 06.09.04.004; 14.11.01.016; 19.07.03.0060.023510%-
Tremor17.01.06.002--
Urticaria10.01.06.001; 23.04.02.001--
Vasculitis10.02.02.006; 24.12.04.0270.061126%
Vasculitis necrotising10.02.02.008; 24.12.04.0290.014106%-
Vertigo04.04.01.003; 17.02.12.002--
Visual impairment06.02.10.013---
Vomiting07.01.07.003--
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ADReCS-Target
Drug Name ADR Term Target
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