| Drug Name |
Pravastatin sodium |
| Drug ID |
BADD_D01825 |
| Description |
Pravastatin is the 6-alpha-hydroxy acid form of [mevastatin].[T303] Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug.[T274] This drug was developed by Sankyo Co. Ltd.; however, the first approved pravastatin product was developed by Bristol Myers Squibb and FDA approved in 1991.[L6142]
Pravastatin is made through a fermentation process in which [mevastatin] is first obtained. The manufacturing process is followed by the hydrolysis of the lactone group and the biological hydroxylation with _Streptomyces carbophilus_ to introduce the allylic 6-alcohol group.[T239] |
| Indications and Usage |
Pravastatin is indicated for primary prevention of coronary events hypercholesterolemic patients without clinical evidence of coronary heart disease. Its use includes the reduction of risk on myocardial infarction, undergoing myocardial revascularization procedures and cardiovascular mortality.[T274]
As well, pravastatin can be used as a secondary prevention agent for cardiovascular events in patients with clinically evident coronary heart disease. This indication includes the reduction of risk of total mortality by reducing coronary death, myocardial infarction, undergoing myocardial revascularization procedures, stroke, and stroke/transient ischemic attack as well as to slow the progression of coronary atherosclerosis.[T274]
The term cardiovascular events correspond to all the incidents that can produce damage to the heart muscle including the interruption of blood flow.[L6028]
As adjunctive therapy to diet, pravastatin is used in:
- Patients with primary hypercholesterolemia and mixed dyslipidemias including hyperlipidemia type IIa and IIb.
- Patients with elevated serum triglycerides including type IV hyperlipidemia.
- Patients with heterozygous familial hypercholesterolemia in patients over 8 years of age with low-density lipoprotein (LDL) cholesterol higher than 190 mg/dl after diet modifications or LDL levels higher than 160 mg/dl and familial history of premature cardiovascular diseases or at least two cardiovascular risk factors.[T274]
In patients that do not respond adequately to diet, pravastatin is used to treat patients with primary dysbetalipoproteinemia (type III hyperlipidemia).[T274]
Dyslipidemia is defined as an elevation of plasma cholesterol, triglycerides or both as well as to the presence of low levels of high-density lipoprotein. This condition represents an increased risk for the development of atherosclerosis.[L6025] |
| Marketing Status |
approved |
| ATC Code |
C10AA03 |
| DrugBank ID |
DB00175
|
| KEGG ID |
D00893
|
| MeSH ID |
D017035
|
| PubChem ID |
16759173
|
| TTD Drug ID |
D02RQU
|
| NDC Product Code |
72789-161; 51846-1022; 42291-669; 50090-2024; 51655-976; 55111-229; 55700-994; 60505-0168; 63629-8909; 71205-294; 71335-0947; 71335-1243; 72162-1711; 72789-143; 16714-558; 0093-0771; 0093-7270; 43063-807; 60760-421; 63629-8835; 63629-8836; 68180-488; 68382-073; 68462-196; 70934-549; 0904-5892; 65862-634; 43063-443; 51655-708; 55111-274; 61919-707; 63187-415; 63629-7508; 63629-8906; 63629-8912; 65862-633; 65862-635; 68788-7660; 55111-231; 55154-7998; 57237-164; 61919-708; 63187-413; 63629-8904; 0480-7270; 70518-0549; 70518-1938; 71205-121; 71610-637; 0904-5893; 16729-009; 35356-919; 43063-444; 50090-0975; 50268-668; 51655-073; 60505-0169; 61919-709; 68382-070; 68382-071; 68788-7009; 68788-7779; 68788-8425; 70934-418; 71205-149; 71335-0692; 72162-1707; 72189-059; 72189-119; 82009-007; 0904-5891; 16714-560; 42291-667; 42291-668; 50268-667; 51655-343; 55111-230; 57237-165; 60687-169; 61919-801; 63629-8905; 65862-632; 68180-487; 68462-195; 68788-7584; 71205-516; 71335-0296; 16714-570; 16729-010; 43063-808; 50090-3258; 50090-6145; 51079-458; 51079-782; 60687-190; 63187-732; 63629-8833; 63629-8913; 63629-9165; 68462-197; 68462-198; 70518-2505; 70518-2887; 71335-0101; 71335-1022; 58623-0123; 68254-0004; 0093-7202; 42291-665; 51655-070; 55154-5365; 55154-7275; 60505-0170; 60687-178; 63629-8910; 63629-8911; 63629-9162; 63629-9163; 65841-741; 68180-485; 70377-047; 0615-8029; 72189-061; 65727-003; 16714-559; 16729-008; 0093-7201; 35356-125; 35356-921; 43353-964; 50090-5809; 50090-5927; 55154-5370; 63187-731; 63629-9164; 65841-742; 68382-072; 68788-8421; 0615-8410; 82009-006; 50090-1594; 50090-2025; 50090-3853; 50090-4206; 51655-594; 57237-166; 60505-1323; 65841-739; 65841-740; 68180-486; 70377-045; 70377-046; 70377-048; 70518-1157; 71335-9692; 0615-8030; 72162-1706; 72189-060; 82009-008; 16729-011; 43353-966; 50090-1533; 50268-665; 50268-666; 57237-167 |
| UNII |
3M8608UQ61
|
| Synonyms |
Pravastatin | Eptastatin | Vasten | CS-514 | CS 514 | CS514 | Lin-Pravastatin | Lin Pravastatin | Lipemol | Liplat | Nu-Pravastatin | Nu Pravastatin | Prareduct | Mevalotin | Pravachol | Elisor | Selektine | Lipostat | Pravacol | Pravasin | Pravastatin Monosodium Salt, (6 beta)-Isomer | Pravastatin Sodium | Pravastatin Sodium Salt | Sodium Salt, Pravastatin | Pravastatin tert-Octylamine Salt | Pravastatin tert Octylamine Salt | Pravastatin, (6 beta)-Isomer | RMS-431 | RMS 431 | RMS431 | SQ-31000 | SQ 31000 | SQ31000 | SQ-31,000 | SQ 31,000 | SQ31,000 | Apo-Pravastatin | Apo Pravastatin | Bristacol |
